Epitope analysis of human monoclonal antibodies from a patient with autoimmune factor XIII deficiency reveals their inhibitory mechanisms
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Letters"
DOI: 10.1002/1873-3468.14606
Abstract: Autoimmune coagulation factor XIII (FXIII) deficiency (AiF13D) is a bleeding disorder caused by anti‐FXIII autoantibodies. Recently, we generated human monoclonal antibodies (mAbs) from the peripheral blood of an AiF13D patient and classified them into three… read more here.
Keywords: factor xiii; monoclonal antibodies; human monoclonal; deficiency ... See more keywords
Effect of factor XIII levels and polymorphisms on the risk of myocardial infarction in young patients
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-018-3326-8
Abstract: Factor XIII (FXIII) stabilizes and protects the fibrin network. Its role in myocardial infarction (MI) is still to be clarified. To evaluate the association of FXIII levels with MI in young patients and to investigate… read more here.
Keywords: fxiii; risk; young patients; myocardial infarction ... See more keywords
Increased coagulation factor XIII activity but not genetic variants of coagulation factors is associated with myocardial infarction in young patients
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-019-01856-3
Abstract: The aim of the study was to investigate the possible role of coagulation factor XIII (FXIII) plasma activity and its gene (F13A1) Val34Leu variant as well as thrombospondin-2 gene (THBS2) T/G 3′UTR and thrombospondin-4 gene… read more here.
Keywords: coagulation; young patients; genetic variants; group ... See more keywords
Identification of novel pathogenic F13A1 mutation and novel NBEAL2 gene missense mutation in a pedigree with hereditary congenital factor XIII deficiency.
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2019.03.067
Abstract: The genetic defects of a 12-year-old patient with factor XIII deficiency (FXIIID) and eight pedigree members suspected with FXIIID were studied. Clinical diagnosis, pedigree investigation, phenotypic study and genetic analysis were performed. DNA sequence analysis… read more here.
Keywords: novel; factor xiii; f13a1; nbeal2 gene ... See more keywords
Transglutaminase Activities of Blood Coagulant Factor XIII Are Dependent on the Activation Pathways and on the Substrates
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DOI: 10.1055/a-1993-4193
Abstract: Factor XIII (FXIII) catalyzes formation of γ-glutamyl-ε-lysyl crosslinks between reactive glutamines (Q) and lysines (K). In plasma, FXIII is activated proteolytically (FXIII-A*) by the concerted action of thrombin and Ca2+. Cellular FXIII is activated non-proteolytically… read more here.
Keywords: factor xiii; fbg 233; fxiii; activation ... See more keywords
Antibodies against Noncatalytic B Subunit of Factor XIII Inhibit Activation of Factor XIII and Fibrin Crosslinking
Sign Up to like & getrecommendations! Published in 2022 at "Thrombosis and Haemostasis"
DOI: 10.1055/a-2057-8710
Abstract: BACKGROUND Coagulation factor XIII (FXIII) is a proenzyme of plasma transglutaminase. It comprises two catalytic A subunits (FXIII-A) and two carrier B subunits (FXIII-B). We previously reported that alloantibodies against FXIII-B could promote FXIII clearance… read more here.
Keywords: factor xiii; fibrin crosslinking; fxiii; activation ... See more keywords
Hyperfibrinolysis secondary to acquired factor XIII deficiency A case report
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000029446
Abstract: Introduction: Hyperfibrinolysis induced by factor XIII deficiency (FXIIID) is extremely rare, and patients with no manifestations of active bleeding can easily and frequently be neglected in clinical practice, leading to a missed diagnosis. Herein, we… read more here.
Keywords: factor xiii; factor; hyperfibrinolysis; xiii deficiency ... See more keywords
Selective Plasma Exchange for the Removal of Pemphigus Autoantibodies, Fibrinogen, and Factor XIII in Pemphigus Vulgaris
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DOI: 10.1111/1744-9987.12555
Abstract: Pemphigus vulgaris is a serious autoimmune skin disorder associated with desmoglein 1 and 3. Selective plasma exchange (SePE) for pemphigus vulgaris remains unknown. We investigated the removal characteristics of pemphigus autoantibodies, immunoglobulins, and fibrinogen in… read more here.
Keywords: pemphigus vulgaris; factor xiii; selective plasma; pemphigus autoantibodies ... See more keywords
Defective α2antiplasmin cross‐linking and thrombus stability in a case of acquired factor XIII deficiency
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Haematology"
DOI: 10.1111/bjh.14759
Abstract: Acquired factor XIII (FXIII) deficiency is a rare and life‐threatening condition that is often misdiagnosed or missed completely. A 72‐year‐old woman presented with symptoms of major unprovoked bleeding but routine coagulation screening tests and platelet… read more here.
Keywords: fxiii; factor xiii; acquired factor; cross ... See more keywords
Congenital factor XIII deficiency: comprehensive overview of the FranceCoag cohort
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DOI: 10.1111/bjh.16133
Abstract: This FranceCoag network study assessed 33 patients with congenital factor XIII (FXIII) deficiency presenting FXIII levels read more here.
Keywords: deficiency; factor xiii; congenital factor; francecoag ... See more keywords
The first case report of a patient with acquired factor XIII deficiency in the context of autoimmune encephalitis
Sign Up to like & getrecommendations! Published in 2017 at "Haemophilia"
DOI: 10.1111/hae.13281
Abstract: 8. Venselaar H, Te Beek TA, Kuipers RK, et al. Protein structure analysis of mutations causing inheritable diseases. An eScience approach with life scientist friendly interfaces. BMC Bioinformatics. 2010;11:548. 9. Choi Y, Sims GE, Murphy… read more here.
Keywords: acquired factor; patient acquired; report patient; first case ... See more keywords