When Cofactors Aren't X Factors: Functional Groups That Are Labile in Human Liver Microsomes in the Absence of NADPH.
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.2c00071
Abstract: The metabolic stability of compounds is often assessed at an early stage in drug discovery programs by profiling with hepatic microsomes. Exclusion of the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) in these assays… read more here.
Keywords: mediated metabolism; cofactors factors; functional groups; factors functional ... See more keywords
Prognostic factors of functional outcome after hip fracture surgery: a systematic review
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DOI: 10.1093/ageing/afy057
Abstract: Objective this systematic review aimed to identify immutable and modifiable prognostic factors of functional outcomes and their proposed mechanism after hip fracture surgery. Design systematic search of MEDLINE, Embase, CINAHL, PEDRO, OpenGrey and ClinicalTrials.gov for… read more here.
Keywords: factors functional; hip fracture; functional outcome; prognostic factors ... See more keywords
Open Globe Injuries: Classifications and Prognostic Factors for Functional Outcome
Sign Up to like & getrecommendations! Published in 2021 at "Diagnostics"
DOI: 10.3390/diagnostics11101851
Abstract: This paper explored epidemiology and evaluation of posterior segment involvement as prognostic factors for functional outcome of patients with open globe injuries. A retrospective analysis of 151 patients with open globe injuries was conducted. Pre-… read more here.
Keywords: outcome; open globe; prognostic factors; factors functional ... See more keywords