Abstract 1162: The evaluation of INCB059872, an FAD-directed covalent inhibitor of LSD1, in preclinical models of Ewing sarcoma
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DOI: 10.1158/1538-7445.am2017-1162
Abstract: Ewing sarcoma is a rare bone cancer affecting predominantly children. The chromosomal translocation of chromosomes 11 and 22 results in the EWS/FLI gene fusion oncoprotein that is associated with ~85% of Ewing sarcoma cases. The… read more here.
Keywords: fad directed; ews fli; incb059872; ewing sarcoma ... See more keywords
Abstract 1893: The evaluation of INCB059872, an FAD-directed inhibitor of LSD1, in preclinical models of T-ALL
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DOI: 10.1158/1538-7445.am2018-1893
Abstract: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological tumor that is derived from the clonal expansion of immature T-cell progenitors. Multiple genetic and epigenetic alterations are attributed to the development of malignant T cell… read more here.
Keywords: fad directed; incb059872; evaluation; preclinical models ... See more keywords