Vortioxetine administration attenuates cognitive and synaptic deficits in 5×FAD mice
Sign Up to like & getrecommendations! Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05452-9
Abstract: Rationale and objective Vortioxetine has been reported to exhibit a variety of neurobiological functions and neuroprotective effects. In the present study, we aimed to investigate the effects of vortioxetine on cognitive performance in a transgenic… read more here.
Keywords: mice vortioxetine; amyloid plaques; mice; vortioxetine administration ... See more keywords
Inhibition of EHMT1/2 rescues synaptic and cognitive functions for Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2019 at "Brain"
DOI: 10.1093/brain/awy354
Abstract: Epigenetic dysregulation, which leads to the alteration of gene expression in the brain, is suggested as one of the key pathophysiological bases of ageing and neurodegeneration. Here we found that, in the late-stage familial Alzheimer's… read more here.
Keywords: alzheimer disease; synaptic cognitive; disease; fad mice ... See more keywords
BKCa nitrosylation is associated with cerebral microvascular dysfunction in female 5x-FAD mice
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5731336
Abstract: Vasculopathy and nitro-oxidative stress are present in patients with Alzheimer’s disease (AD) and may contribute to disease progression and severity. Large conductance calcium activated K+ channels (BKCa) plays an important role in vasodilatory responses and… read more here.
Keywords: fad mice; physiology; female fad; fad ... See more keywords
Panax Notoginseng Saponin Rg1 Can Effectively Improve the Cognitive Function of 5 × FAD Mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Healthcare Engineering"
DOI: 10.1155/2022/5152761
Abstract: In order to investigate the effect of notoginsenoside Rg1 on cognitive function in 5∗FAD mice and the mechanism of Cx43 in improving cognitive function in mice, the methods 5∗FAD mice are selected as experimental animals… read more here.
Keywords: fad mice; cognitive function; group; mice ... See more keywords
Cyclooxygenase-1 deletion in 5 × FAD mice protects against microglia-induced neuroinflammation and mitigates cognitive impairment
Sign Up to like & getrecommendations! Published in 2025 at "Translational Neurodegeneration"
DOI: 10.1186/s40035-025-00501-9
Abstract: Alzheimer's disease (AD) is a neurodegenerative disease with major symptoms including memory and learning deficits. Neuroinflammation associated with reactive microglia promotes AD progression. These reactive microglia secrete prostaglandins, which are synthesized through the enzymatic activity… read more here.
Keywords: mice; neuroinflammation; cyclooxygenase; fad mice ... See more keywords
Amyloid β-induced Mesenteric Inflammation in an Alzheimer's Disease Transgenic Mouse Model.
Sign Up to like & getrecommendations! Published in 2020 at "Current Alzheimer research"
DOI: 10.2174/1567205017666200212160343
Abstract: BACKGROUND Alzheimer's disease (AD) is a neurodegenerative disorder histopathologically characterized by the accumulation of amyloid β (Aβ) peptides and inflammation associated with activated microglia. These features are well investigated in the central nervous system using… read more here.
Keywords: alzheimer disease; inflammation; model; mice ... See more keywords
7-α-O-Methylmorroniside ameliorated brain injury in 5×FAD mice by regulating the gut microbiome and NMDAR2B
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2025.1545566
Abstract: Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive decline. 7-α-O-Methylmorroniside (MorA), an iridoid glycoside extracted from Cornus officinalis Sieb. et Zucc., has been shown to have neuroprotective effects, but the mechanism of its… read more here.
Keywords: fad mice; injury fad; brain injury; brain ... See more keywords
Enhanced Anxiety and Olfactory Microglial Activation in Early-Stage Familial Alzheimer’s Disease Mouse Model
Sign Up to like & getrecommendations! Published in 2022 at "Biology"
DOI: 10.3390/biology11060938
Abstract: Simple Summary We observed that compared to wildtype (WT) littermates, 5 × FAD mice showed enhanced anxiety with concomitant increased pro-inflammatory cytokines in the olfactory bulb (OB) but not the frontal cortex (FC) at as… read more here.
Keywords: fad mice; microglial activation; enhanced anxiety; stage ... See more keywords
Co-Aggregation of Syndecan-3 with β-Amyloid Aggravates Neuroinflammation and Cognitive Impairment in 5×FAD Mice
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms26125502
Abstract: Abnormal deposition of β-amyloid (Aβ) is a core pathological feature of Alzheimer’s disease (AD). Syndecan-3 (SDC3), a type I transmembrane heparan sulfate proteoglycan (HSPG), is abnormally overexpressed in the brains of AD patients and model… read more here.
Keywords: fad mice; pathology; amyloid; deposition ... See more keywords
Therapeutic Efficacy of the Inositol D-Pinitol as a Multi-Faceted Disease Modifier in the 5×FAD Humanized Mouse Model of Alzheimer’s Amyloidosis
Sign Up to like & getrecommendations! Published in 2024 at "Nutrients"
DOI: 10.3390/nu16234186
Abstract: Background/Objectives: Alzheimer’s disease (AD), a leading cause of dementia, lacks effective long-term treatments. Current therapies offer temporary relief or fail to halt its progression and are often inaccessible due to cost. AD involves multiple pathological… read more here.
Keywords: disease; dpin; fad mice; modifier ... See more keywords