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Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05452-9
Abstract: Rationale and objective Vortioxetine has been reported to exhibit a variety of neurobiological functions and neuroprotective effects. In the present study, we aimed to investigate the effects of vortioxetine on cognitive performance in a transgenic…
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Keywords:
mice vortioxetine;
amyloid plaques;
mice;
vortioxetine administration ... See more keywords
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Published in 2019 at "Brain"
DOI: 10.1093/brain/awy354
Abstract: Epigenetic dysregulation, which leads to the alteration of gene expression in the brain, is suggested as one of the key pathophysiological bases of ageing and neurodegeneration. Here we found that, in the late-stage familial Alzheimer's…
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Keywords:
alzheimer disease;
synaptic cognitive;
disease;
fad mice ... See more keywords
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Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5731336
Abstract: Vasculopathy and nitro-oxidative stress are present in patients with Alzheimer’s disease (AD) and may contribute to disease progression and severity. Large conductance calcium activated K+ channels (BKCa) plays an important role in vasodilatory responses and…
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Keywords:
fad mice;
physiology;
female fad;
fad ... See more keywords
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Published in 2022 at "Journal of Healthcare Engineering"
DOI: 10.1155/2022/5152761
Abstract: In order to investigate the effect of notoginsenoside Rg1 on cognitive function in 5∗FAD mice and the mechanism of Cx43 in improving cognitive function in mice, the methods 5∗FAD mice are selected as experimental animals…
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Keywords:
fad mice;
cognitive function;
group;
mice ... See more keywords
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Published in 2020 at "Current Alzheimer research"
DOI: 10.2174/1567205017666200212160343
Abstract: BACKGROUND Alzheimer's disease (AD) is a neurodegenerative disorder histopathologically characterized by the accumulation of amyloid β (Aβ) peptides and inflammation associated with activated microglia. These features are well investigated in the central nervous system using…
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Keywords:
alzheimer disease;
inflammation;
model;
mice ... See more keywords
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Published in 2022 at "Biology"
DOI: 10.3390/biology11060938
Abstract: Simple Summary We observed that compared to wildtype (WT) littermates, 5 × FAD mice showed enhanced anxiety with concomitant increased pro-inflammatory cytokines in the olfactory bulb (OB) but not the frontal cortex (FC) at as…
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Keywords:
fad mice;
microglial activation;
enhanced anxiety;
stage ... See more keywords