How Mutations perturb γ-Secretase active site studied by Free Energy Simulations.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.0c00440
Abstract: γ-secretase is involved in processing of the amyloid precursor protein (APP) and generation of short Aβ-peptides that may play a key role in neurodegenerative diseases such as Alzheimer's Disease (AD). Several mutations in γ-secretase influence… read more here.
Keywords: fad mutations; active site; geometry; free energy ... See more keywords
Specific Mutations in Aph1 Cause γ-Secretase Activation
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23010507
Abstract: Amyloid beta peptides (Aβs) are generated from amyloid precursor protein (APP) through multiple cleavage steps mediated by γ-secretase, including endoproteolysis and carboxypeptidase-like trimming. The generation of neurotoxic Aβ42/43 species is enhanced by familial Alzheimer’s disease… read more here.
Keywords: function; aph1 cause; fad mutations; secretase ... See more keywords