Reprogramming of Fatty Acid Metabolism via PPARα‐Orchestrated FADS2 in Keratinocytes Modulates Skin Inflammation in Psoriasis
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202417049
Abstract: Psoriasis is a chronic inflammatory skin disorder characterized by keratinocyte hyper‐proliferation and immune dysregulation. Recent evidence has implicated dysregulated polyunsaturated fatty acid (PUFA) metabolism in its pathogenesis. In this study, fatty acid desaturase 2 (FADS2),… read more here.
Keywords: metabolism; skin inflammation; inflammation; fads2 ... See more keywords
Capacity for eicosapentaenoic acid and arachidonic acid biosynthesis in silver barb (Barbonymus gonionotus): Functional characterisation of a Δ6/Δ8/Δ5 Fads2 desaturase and Elovl5 elongase
Sign Up to like & getrecommendations! Published in 2018 at "Aquaculture"
DOI: 10.1016/j.aquaculture.2018.08.019
Abstract: Abstract The silver barb (Barbonymus gonionotus), a widely distributed cyprinid in Southeast Asia, has a reasonable deposition of the physiologically important omega-3 (n-3) long-chain polyunsaturated fatty acids (LC-PUFA), implying the existence of a functional LC-PUFA… read more here.
Keywords: biosynthesis; acid; silver barb; fads2 ... See more keywords
High fat / high cholesterol diet does not provoke atherosclerosis in the ω3-and ω6-polyunsaturated fatty acid synthesis–inactivated Δ6-fatty acid desaturase–deficient mouse
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2021.101335
Abstract: Objective An increased ω6/ω3-polyunsaturated fatty acid ratio in the current Western diet is regarded as a critical epigenetic nutritional factor in the pathogenesis of several human lifestyle diseases, metabolic syndrome, cardiovascular disease, the central nervous… read more here.
Keywords: synthesis; fatty acid; pufas; fads2 ... See more keywords
Functional diversification of teleost Fads2 fatty acyl desaturases occurs independently of the trophic level
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-47709-0
Abstract: The long-chain (≥C20) polyunsaturated fatty acid biosynthesis capacity of fish varies among species, with trophic level hypothesised as a major factor. The biosynthesis capacity is largely dependent upon the presence of functionally diversified fatty acyl… read more here.
Keywords: trophic level; diversification teleost; teleost fads2; fads2 ... See more keywords
Copy number variation of a fatty acid desaturase gene Fads2 associated with ecological divergence in freshwater stickleback populations
Sign Up to like & getrecommendations! Published in 2021 at "Biology Letters"
DOI: 10.1098/rsbl.2021.0204
Abstract: Fitness of aquatic animals can be limited by the scarcity of nutrients such as long-chain polyunsaturated fatty acids, especially docosahexaenoic acid (DHA). DHA availability from diet varies among aquatic habitats, imposing different selective pressures on… read more here.
Keywords: copy number; fatty acid; fads2; freshwater ... See more keywords
Risk SNP-Mediated Enhancer–Promoter Interaction Drives Colorectal Cancer through Both FADS2 and AP002754.2
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/0008-5472.can-19-2389
Abstract: This study provides an oncogenic regulatory circuit among several oncogenes including E2F1, FADS2, and AP002754.2 underlying the association of rs174575 with the colorectal cancer risk, which is driven by long-range enhancer-promoter interaction loops. Although genome-wide… read more here.
Keywords: fads2; cancer; risk; enhancer promoter ... See more keywords
Genetic Variants Affecting FADS2 Enzyme Dynamics and Gene Expression in Cogenetic Oysters with Different PUFA Levels Provide New Tools to Improve Unsaturated Fatty Acids
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms252413551
Abstract: Long-chain polyunsaturated fatty acids (LC-PUFAs) are crucial for human health and cannot be produced internally. Bivalves, such as oysters, serve as valuable sources of high-quality PUFAs. The enzyme fatty acid desaturase (FADS) plays a key… read more here.
Keywords: pufa levels; enzyme; genetic variants; fatty acids ... See more keywords