Capacity for eicosapentaenoic acid and arachidonic acid biosynthesis in silver barb (Barbonymus gonionotus): Functional characterisation of a Δ6/Δ8/Δ5 Fads2 desaturase and Elovl5 elongase
Sign Up to like & getrecommendations! Published in 2018 at "Aquaculture"
DOI: 10.1016/j.aquaculture.2018.08.019
Abstract: Abstract The silver barb (Barbonymus gonionotus), a widely distributed cyprinid in Southeast Asia, has a reasonable deposition of the physiologically important omega-3 (n-3) long-chain polyunsaturated fatty acids (LC-PUFA), implying the existence of a functional LC-PUFA… read more here.
Keywords: biosynthesis; acid; silver barb; fads2 ... See more keywords
High fat / high cholesterol diet does not provoke atherosclerosis in the ω3-and ω6-polyunsaturated fatty acid synthesis–inactivated Δ6-fatty acid desaturase–deficient mouse
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2021.101335
Abstract: Objective An increased ω6/ω3-polyunsaturated fatty acid ratio in the current Western diet is regarded as a critical epigenetic nutritional factor in the pathogenesis of several human lifestyle diseases, metabolic syndrome, cardiovascular disease, the central nervous… read more here.
Keywords: synthesis; fatty acid; pufas; fads2 ... See more keywords
Functional diversification of teleost Fads2 fatty acyl desaturases occurs independently of the trophic level
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DOI: 10.1038/s41598-019-47709-0
Abstract: The long-chain (≥C20) polyunsaturated fatty acid biosynthesis capacity of fish varies among species, with trophic level hypothesised as a major factor. The biosynthesis capacity is largely dependent upon the presence of functionally diversified fatty acyl… read more here.
Keywords: trophic level; diversification teleost; teleost fads2; fads2 ... See more keywords
Copy number variation of a fatty acid desaturase gene Fads2 associated with ecological divergence in freshwater stickleback populations
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DOI: 10.1098/rsbl.2021.0204
Abstract: Fitness of aquatic animals can be limited by the scarcity of nutrients such as long-chain polyunsaturated fatty acids, especially docosahexaenoic acid (DHA). DHA availability from diet varies among aquatic habitats, imposing different selective pressures on… read more here.
Keywords: copy number; fatty acid; fads2; freshwater ... See more keywords
Risk SNP-Mediated Enhancer–Promoter Interaction Drives Colorectal Cancer through Both FADS2 and AP002754.2
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DOI: 10.1158/0008-5472.can-19-2389
Abstract: This study provides an oncogenic regulatory circuit among several oncogenes including E2F1, FADS2, and AP002754.2 underlying the association of rs174575 with the colorectal cancer risk, which is driven by long-range enhancer-promoter interaction loops. Although genome-wide… read more here.
Keywords: fads2; cancer; risk; enhancer promoter ... See more keywords