FAF1 blocks ferroptosis by inhibiting peroxidation of polyunsaturated fatty acids.
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2107189119
Abstract: SignificanceThe current study reveals the functions of FAF1 in protecting cells from ferroptosis, a novel cell death pathway triggered by PUFA peroxidation. In the absence of FAF1, cultured cells and mice are extremely sensitive to… read more here.
Keywords: peroxidation; faf1; inhibiting peroxidation; ferroptosis inhibiting ... See more keywords
The complex of Fas-associated factor 1 with Hsp70 stabilizes the adherens junction integrity by suppressing RhoA activation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjac037
Abstract: Abstract Fas-associated factor 1 (FAF1) is a scaffolding protein that plays multiple functions, and dysregulation of FAF1 is associated with many types of diseases such as cancers. FAF1 contains multiple ubiquitin-related domains (UBA, UBL1, UBL2,… read more here.
Keywords: rhoa activation; adherens junction; faf1; hsp70 ... See more keywords
Fas-associated factor 1 mediates NADPH oxidase-induced reactive oxygen species production and proinflammatory responses in macrophages against Listeria infection
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1008004
Abstract: Fas-associated factor 1 is a death-promoting protein that induces apoptosis by interacting with the Fas receptor. Until now, FAF1 was reported to interact potentially with diverse proteins and to function as a negative and/or positive… read more here.
Keywords: faf1; production; infection; fas associated ... See more keywords
Long non‑coding RNA FAF1 promotes intervertebral disc degeneration by targeting the Erk signaling pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular medicine reports"
DOI: 10.3892/mmr.2017.8237
Abstract: Intervertebral disc degeneration (IDD) has become the most common cause of low‑back pain, and it imposes a heavy burden on patients with IDD and society. The effects of long non‑coding RNAs on the proliferation and… read more here.
Keywords: faf1; signaling pathway; expression; erk signaling ... See more keywords