Failed clinical trials on COVID-19 acute respiratory distress syndrome in hospitalized patients: common oversights and streamlining the development of clinically effective therapeutics
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2022.2120801
Abstract: ABSTRACT Introduction The coronavirus disease 2019 (COVID-19) pandemic has put a strain on global healthcare systems. Despite admirable efforts to develop rapidly new pharmacotherapies, supportive treatments remain the standard of care. Multiple clinical trials have… read more here.
Keywords: hospitalized patients; effective therapeutics; clinical trials; oversights streamlining ... See more keywords
Why has immune “checkpoint” therapy failed in most clinical trials?
Sign Up to like & getrecommendations! Published in 2025 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2025-012457
Abstract: Cancer immunotherapy targeting the PD-1/PD-L1 pathway has demonstrated efficacy across a range of common solid tumors and some hematopoietic malignancies. Despite these groundbreaking successes, the clinical development of other ‘checkpoint inhibitors’ targeting molecules like TIM-3,… read more here.
Keywords: therapy failed; therapy; immune checkpoint; failed clinical ... See more keywords