Myocardial oedema: pathophysiological basis and implications for the failing heart
Sign Up to like & getrecommendations! Published in 2022 at "ESC Heart Failure"
DOI: 10.1002/ehf2.13775
Abstract: Myocardial fluid homeostasis relies on a complex interplay between microvascular filtration, interstitial hydration, cardiomyocyte water uptake and lymphatic removal. Dysregulation of one or more of these mechanisms may result in myocardial oedema. Interstitial and intracellular… read more here.
Keywords: heart; heart failure; myocardial oedema; pathophysiological basis ... See more keywords
Accumulation of gold nano-rods in the failing heart of transgenic mice with the cardiac-specific expression of TNF-α
Sign Up to like & getrecommendations! Published in 2018 at "Heart and Vessels"
DOI: 10.1007/s00380-018-1241-2
Abstract: Gold nano-rods, rod-shaped gold nanoparticles, act as contrast agents for in vivo bioimaging, drug delivery vehicles and thermal converters for photothermal therapy. Pro-inflammatory cytokines play critical roles in the development of heart failure. We examined… read more here.
Keywords: failing heart; heart transgenic; heart; gold nano ... See more keywords
Phosphodiesterase expression in the normal and failing heart.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2018.12.013
Abstract: The number of patients with heart failure with reduced ejection fraction (HFrEF) and preserved ejection fraction (HFpEF) is increasing, and for HFpEF, no therapies have clinical benefit. It has been hypothesized that PKG attenuates pathological… read more here.
Keywords: expression normal; failing heart; normal failing; heart ... See more keywords
P1661The myocardial tissue Renin-Angiotensin-System (RAS) of the failing heart
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehz748.0419
Abstract: Prognosis of patients with HFrEF remains poor despite recent advances in pharmacologic therapy as the introduction of the angiotensin-receptor neprilysin-inhibitor (ARNI). The Renin-Angiotensin-System (RAS) is dysregulated in HF with elevated AngII levels as a central… read more here.
Keywords: failing heart; heart; myocardial tissue; tissue ... See more keywords
Limits of ventricular function: from athlete's heart to a failing heart
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Physiology and Functional Imaging"
DOI: 10.1111/cpf.12341
Abstract: The interest in the study of ventricular function has grown considerably in the last decades. In this review, we analyse the extreme values of ventricular function as obtained with Doppler echocardiography. We mainly focus on… read more here.
Keywords: failing heart; ventricular function; heart; function athlete ... See more keywords
Effective Metabolic Approaches for the Energy Starved Failing Heart: Bioenergetic Resiliency via Redundancy or Something Else?
Sign Up to like & getrecommendations! Published in 2018 at "Circulation Research"
DOI: 10.1161/circresaha.118.313308
Abstract: One of the major unresolved questions in cardiovascular physiology is which steps in the cascade of carbon substrate preference, mitochondrial ATP production, conduction, and utilization ultimately limit maximal performance of a normal heart or contribute… read more here.
Keywords: failing heart; heart; capacity; energy ... See more keywords
Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy
Sign Up to like & getrecommendations! Published in 2018 at "Circulation"
DOI: 10.1161/circulationaha.116.026099
Abstract: Background: Myocardial metabolic impairment is a major feature in chronic heart failure. As the major coenzyme in fuel oxidation and oxidative phosphorylation and a substrate for enzymes signaling energy stress and oxidative stress response, nicotinamide… read more here.
Keywords: failing heart; heart; heart failure; nicotinamide riboside ... See more keywords
323-OR: SGLT2 Inhibition Promotes Myocardial Ketone Utilization in the Normal and Failing Heart
Sign Up to like & getrecommendations! Published in 2021 at "Diabetes"
DOI: 10.2337/db21-323-or
Abstract: Recent clinical outcome studies demonstrate that SGLT2 inhibitors (i) significantly reduce major adverse cardiovascular events and heart failure in patients with and without type 2 diabetes; however, the mechanisms by which SGLT2i exert their cardiovascular… read more here.
Keywords: failing heart; normal failing; heart; 323 sglt2 ... See more keywords
Loss of Metabolic Flexibility in the Failing Heart
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2018.00068
Abstract: To maintain its high energy demand the heart is equipped with a highly complex and efficient enzymatic machinery that orchestrates ATP production using multiple energy substrates, namely fatty acids, carbohydrates (glucose and lactate), ketones and… read more here.
Keywords: failing heart; heart; oxidation; energy ... See more keywords
Targeting Mitochondrial Metabolism to Save the Failing Heart
Sign Up to like & getrecommendations! Published in 2023 at "Life"
DOI: 10.3390/life13041027
Abstract: Despite considerable progress in treating cardiac disorders, the prevalence of heart failure (HF) keeps growing, making it a global medical and economic burden. HF is characterized by profound metabolic remodeling, which mostly occurs in the… read more here.
Keywords: metabolism save; failing heart; mitochondrial metabolism; save failing ... See more keywords