ZBP1 Protects Against mtDNA-Induced Myocardial Inflammation in Failing Hearts
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DOI: 10.1161/circresaha.122.322227
Abstract: Background: Mitochondrial DNA (mtDNA)-induced myocardial inflammation is intimately involved in cardiac remodeling. ZBP1 (Z-DNA binding protein 1) is a pattern recognition receptor positively regulating inflammation in response to mtDNA in inflammatory cells, fibroblasts, and endothelial… read more here.
Keywords: inflammation; mtdna induced; failing hearts; myocardial inflammation ... See more keywords
Fibroblast-Specific Proteotranscriptomes Reveal Distinct Fibrotic Signatures of Human Sinoatrial Node in Nonfailing and Failing Hearts
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DOI: 10.1161/circulationaha.120.051583
Abstract: Supplemental Digital Content is available in the text. Background: Up to 50% of the adult human sinoatrial node (SAN) is composed of dense connective tissue. Cardiac diseases including heart failure (HF) may increase fibrosis within… read more here.
Keywords: sinoatrial node; human sinoatrial; fibroblast specific; failing hearts ... See more keywords
Why Diuretics Fail Failing Hearts.
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DOI: 10.1681/asn.2017070797
Abstract: Loop diuretics represent a key component of the therapeutic armamentarium used to reduce extracellular fluid volume in heart failure. Unfortunately, resistance to loop diuretics commonly occurs, complicating clinical management. In general, diuretic resistance refers to… read more here.
Keywords: diuretics fail; nephrology; fail failing; failing hearts ... See more keywords