Regional Differences in mRNA and lncRNA Expression Profiles in Non-Failing Human Atria and Ventricles
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DOI: 10.1038/s41598-018-32154-2
Abstract: The four chambers of the human heart play distinct roles in the maintenance of normal cardiac function, and are differentially affected by inherited/acquired cardiovascular disease. To probe the molecular determinants of these functional differences, we… read more here.
Keywords: lncrna expression; expression profiles; mrna lncrna; non failing ... See more keywords
Stretching Single Titin Molecules from Failing Human Hearts Reveals Titin's Role in Blunting Cardiac Kinetic Reserve.
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DOI: 10.1093/cvr/cvz043
Abstract: AIMS Heart failure patients commonly experience symptoms primarily during elevated heart rates, as a result of physical activities or stress. A main determinant of diastolic passive tension, the elastic sarcomeric protein titin, has been shown… read more here.
Keywords: human hearts; titin; heart; role ... See more keywords
Normalization strategy for selection of reference genes for RT-qPCR analysis in left ventricles of failing human hearts
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DOI: 10.1186/s12872-022-02614-9
Abstract: Background Quantitative RT-PCR is a valuable tool for assessing the gene expression in different human tissues, particularly due to its exceptional sensitivity, accuracy and reliability. However, the choice of adequate control for normalization is a crucial… read more here.
Keywords: left ventricles; reference; human hearts; selection ... See more keywords
Mass Spectrometry-Based Redox and Protein Profiling of Failing Human Hearts
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DOI: 10.3390/ijms22041787
Abstract: Oxidative stress contributes to detrimental functional decline of the myocardium, leading to the impairment of the antioxidative defense, dysregulation of redox signaling, and protein damage. In order to precisely dissect the changes of the myocardial… read more here.
Keywords: human hearts; based redox; mass spectrometry; failing human ... See more keywords