Effect of Sacubitril/Valsartan vs Valsartan on Left Atrial Volume in Patients With Pre–Heart Failure With Preserved Ejection Fraction
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Cardiology"
DOI: 10.1001/jamacardio.2023.0065
Abstract: Key Points Question Can neprilysin inhibition improve markers of cardiovascular structure and function in patients with pre–heart failure with preserved ejection fraction? Findings In this randomized clinical trial of 250 asymptomatic patients, sacubitril/valsartan vs valsartan… read more here.
Keywords: heart failure; preserved ejection; pre heart; failure preserved ... See more keywords
Optimal Pharmacologic Treatment of Heart Failure With Preserved and Mildly Reduced Ejection Fraction
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.31963
Abstract: Key Points Question What is the optimal drug combination for treatment of heart failure (HF) with preserved ejection fraction (HFpEF) and mildly reduced ejection fraction (HFmrEF)? Findings In this network meta-analysis, 19 randomized clinical trials… read more here.
Keywords: treatment heart; heart failure; failure preserved; ejection ... See more keywords
Detyrosinated α‐tubulin mediates mitochondrial dysfunction and diastolic impairment in heart failure with preserved ejection fraction
Sign Up to like & getrecommendations! Published in 2025 at "FEBS Letters"
DOI: 10.1002/1873-3468.70119
Abstract: Heart failure with preserved ejection fraction (HFpEF) is characterized by diastolic dysfunction, yet its molecular basis remains unclear. Here, we identified detyrosinated α‐tubulin as a key cause of mitochondrial dysfunction and impaired mitophagy in HFpEF.… read more here.
Keywords: detyrosinated tubulin; failure preserved; dysfunction; ejection fraction ... See more keywords
Loss of Hepatic Angiotensinogen Attenuates Diastolic Dysfunction in Heart Failure with Preserved Ejection Fraction
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202507554
Abstract: Heart failure with preserved ejection fraction (HFpEF) is a prevalent complex syndrome characterized by diastolic dysfunction with limited therapeutic options. While the renin‐angiotensin system (RAS) is implicated in heart failure pathogenesis, the causal contribution of… read more here.
Keywords: diastolic dysfunction; failure preserved; heart failure; dysfunction ... See more keywords
Interleukin‐1 blockade in heart failure with preserved ejection fraction: rationale and design of the Diastolic Heart Failure Anakinra Response Trial 2 (D‐HART2)
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Cardiology"
DOI: 10.1002/clc.22719
Abstract: Heart failure with preserved ejection fraction (HFpEF) now accounts for the majority of confirmed HF cases in the United States. However, there are no highly effective evidence‐based treatments currently available for these patients. Inflammation correlates… read more here.
Keywords: failure preserved; trial; heart; anakinra ... See more keywords
Catheter ablation of atrial fibrillation in patients with heart failure and preserved ejection fraction: A meta‐analysis
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Cardiology"
DOI: 10.1002/clc.23841
Abstract: Catheter ablation (CA) is an effective treatment for patients with atrial fibrillation (AF). The potential of CA to benefit AF patients with heart failure and preserved ejection fraction (HFpEF) is uncertain. read more here.
Keywords: heart failure; preserved ejection; failure preserved; patients heart ... See more keywords
The Role of Esaxerenone in the Continuum of Heart Failure With Preserved Ejection Fraction: Insights From a Prospective Observational Study
Sign Up to like & getrecommendations! Published in 2025 at "Clinical Cardiology"
DOI: 10.1002/clc.70137
Abstract: Heart failure with preserved ejection fraction (HFpEF) presents significant therapeutic challenges, particularly exacerbated by comorbidities such as hypertension and diabetes. The modulation of the Renin–Angiotensin–Aldosterone System is critical in managing HFpEF progression. Esaxerenone (ESAX), a… read more here.
Keywords: ejection fraction; heart failure; preserved ejection; failure preserved ... See more keywords
Evaluating the Impact of Catheter Ablation on Cardiovascular and Cerebral Outcomes in Atrial Fibrillation With Heart Failure and Preserved Ejection Fraction
Sign Up to like & getrecommendations! Published in 2025 at "Clinical Cardiology"
DOI: 10.1002/clc.70220
Abstract: Evidence supporting catheter ablation (CA) for atrial fibrillation (AF) in heart failure with preserved ejection fraction (HFpEF) is limited. This study evaluated the impact of CA on clinical outcomes in patients with AF and HFpEF… read more here.
Keywords: fibrillation heart; catheter ablation; failure preserved; heart failure ... See more keywords
Aging and Heart Failure with Preserved Ejection Fraction.
Sign Up to like & getrecommendations! Published in 2022 at "Comprehensive Physiology"
DOI: 10.1002/cphy.c210035
Abstract: Heart failure is a clinical syndrome characterized by the inability of the cardiovascular system to provide adequate cardiac output at normal filling pressures. This results in a clinical syndrome characterized by dyspnea, edema, and decreased… read more here.
Keywords: failure preserved; heart failure; preserved ejection; hfpef ... See more keywords
The effect of exercise training on biventricular myocardial strain in heart failure with preserved ejection fraction
Sign Up to like & getrecommendations! Published in 2017 at "ESC Heart Failure"
DOI: 10.1002/ehf2.12149
Abstract: High‐intensity interval training (HIIT) improves peak oxygen uptake and left ventricular diastology in patients with heart failure with preserved ejection fraction (HFpEF). However, its effects on myocardial strain in HFpEF remain unknown. We explored the… read more here.
Keywords: strain; failure preserved; training; heart failure ... See more keywords
Malnutrition in acute heart failure with preserved ejection fraction: clinical correlates and prognostic implications
Sign Up to like & getrecommendations! Published in 2019 at "ESC Heart Failure"
DOI: 10.1002/ehf2.12501
Abstract: This study aimed to evaluate the prognostic significance of nutritional status in post‐discharge Asians with heart failure with preserved ejection fraction (HFpEF). read more here.
Keywords: ejection fraction; failure preserved; heart; heart failure ... See more keywords