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   Articles with "fak" as a keyword



KIF5A upregulation by FAK-mediated downregulation of epigenetic modifiers promotes mitochondrial dynamics in neuronal differentiation.

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recommendations! Published in 2025 at "FEBS letters"

DOI: 10.1002/1873-3468.70177

Abstract: Neuronal differentiation depends on mitochondrial transport and networking toward the developing axon and dendrites. Herein, we report that the motor protein kinesin family member 5A (KIF5A) is essential for neuronal maturation through regulation of mitochondrial… read more here.

Keywords: differentiation; downregulation epigenetic; epigenetic modifiers; fak ... See more keywords

BI 853520, a FAK-Simile of Prior FAK Inhibitors?

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recommendations! Published in 2019 at "Targeted Oncology"

DOI: 10.1007/s11523-019-00621-z

Abstract: In this issue of Targeted Oncology, the BI 853520 investigators present three complementary studies of BI 853520 that investigate this drug in both Western and Eastern patient populations, as well as investigating the effects of… read more here.

Keywords: fak; kinase; defactinib; cancer ... See more keywords

High glucose/ox-LDL induced hepatic sinusoidal capillarization via αvβ5/FAK/ERK signaling pathway.

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recommendations! Published in 2019 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2019.04.082

Abstract: OBJECTIVE The main purpose of this study is to explore the role of integrin αvβ5 in hepatic sinusoidal capillarization under high glucose/ox-LDL conditions. METHODS Establish rat model of diabetic fatty liver disease. LSECs were extracted… read more here.

Keywords: hepatic sinusoidal; fak; sinusoidal capillarization; high glucose ... See more keywords

Inhibition of SRC/FAK cue: A novel pathway for the synergistic effect of rosuvastatin on the anti‐cancer effect of dasatinib in hepatocellular carcinoma

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recommendations! Published in 2018 at "Life Sciences"

DOI: 10.1016/j.lfs.2018.10.002

Abstract: Purpose: Statins extended their hypocholestremic effect to show a promising anticancer activity. Hepatocellular carcinoma (HCC), the third common cause of cancer‐related death, responded positively to statins. Some in‐vitro studies reveal the rosuvastatin antitumor effect, but… read more here.

Keywords: hepatocellular carcinoma; rosuvastatin; fak; effect ... See more keywords

ADP ribosylation factor guanylate kinase 1 promotes the malignant phenotype of gastric cancer by regulating focal adhesion kinase activation.

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recommendations! Published in 2021 at "Life sciences"

DOI: 10.1016/j.lfs.2021.119264

Abstract: AIMS ADP ribosylation factor guanylate kinase 1 (ASAP1), a phospholipid-dependent guanosine triphosphate (GTP)ase activating protein, has been reported to be involved in the development of various malignant tumors. However, the biological function of ASAP1 in… read more here.

Keywords: fak; kinase; malignant biological; biological behavior ... See more keywords

Cucurbitacin B suppresses metastasis mediated by reactive oxygen species (ROS) via focal adhesion kinase (FAK) in breast cancer MDA-MB-231 cells.

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recommendations! Published in 2018 at "Chinese journal of natural medicines"

DOI: 10.1016/s1875-5364(18)30025-6

Abstract: Metastasis is responsible for the majority of cancer-related deaths and prevention of metastasis remains a big challenge for cancer therapy. Cucurbitacin B (Cuc B) is a natural triterpenoid with potent anticancer activities while its effect… read more here.

Keywords: mda 231; fak; adhesion; breast cancer ... See more keywords

Identification of a Potent and Selective Focal Adhesion Kinase Proteolysis Targeting Chimera: Targeting Noncatalytic Functions of Focal Adhesion Kinase to Facilitate Antitumor Immunity.

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recommendations! Published in 2025 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.5c00921

Abstract: Focal adhesion kinase (FAK) has emerged as a promising therapeutic target since its pivotal involvement in tumorigenesis. However, FAK inhibitors exhibit limited efficacy in suppressing FAK's noncatalytic functions, potentially compromising their therapeutic outcomes. Herein, we… read more here.

Keywords: focal adhesion; fak; kinase; noncatalytic functions ... See more keywords
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Design, Synthesis, and Evaluation of Highly Potent FAK-Targeting PROTACs.

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recommendations! Published in 2020 at "ACS medicinal chemistry letters"

DOI: 10.1021/acsmedchemlett.9b00372

Abstract: Focal adhesion kinase (FAK), a cytoplasmic protein tyrosine kinase, exerts kinase-dependent enzymatic functions and kinase-independent scaffolding functions, both of which are crucial in cancer development, early embryonic development, and reproduction. However, previous efforts for FAK… read more here.

Keywords: highly potent; design synthesis; fak; evaluation highly ... See more keywords

Molecular Docking, Molecular Dynamics Simulations, and Free Energy Calculation Insights into the Binding Mechanism between VS-4718 and Focal Adhesion Kinase

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recommendations! Published in 2022 at "ACS Omega"

DOI: 10.1021/acsomega.2c03951

Abstract: Focal adhesion kinase (FAK) is a 125 kDa nonreceptor tyrosine kinase that plays an important role in many carcinomas. Thus, the targeting of FAK by small molecules is considered to be promising for cancer therapy.… read more here.

Keywords: molecular docking; fak; kinase; adhesion kinase ... See more keywords

Inhibition of the integrin/FAK signaling axis and c-Myc synergistically disrupts ovarian cancer malignancy

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recommendations! Published in 2017 at "Oncogenesis"

DOI: 10.1038/oncsis.2016.86

Abstract: Integrins, a family of heterodimeric receptors for extracellular matrix, are promising therapeutic targets for ovarian cancer, particularly high-grade serous-type (HGSOC), as they drive tumor cell attachment, migration, proliferation and survival by activating focal adhesion kinase… read more here.

Keywords: signaling axis; integrin fak; fak; ovarian cancer ... See more keywords

The binding of DCC-P3 motif and FAK-FAT domain mediates the initial step of netrin-1/DCC signaling for axon attraction

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recommendations! Published in 2017 at "Cell Discovery"

DOI: 10.1038/s41421-017-0008-8

Abstract: Netrin-1 plays a key role in axon guidance through binding to its receptor, Deleted in Colorectal Cancer (DCC). The initial step of signaling inside the cell after netrin-1/DCC ligation is the binding of DCC cytoplasmic… read more here.

Keywords: fat domain; fak; fat; netrin dcc ... See more keywords