PTEN improve renal fibrosis in vitro and in vivo through inhibiting FAK/AKT signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29057
Abstract: Renal fibrosis, the ultimate common pathway of progressive nephropathy, is characterized by excess accumulation and deposition of extracellular matrix (ECM) within the renal interstitium and glomeruli, finally resulting in end‐stage kidney failure. TGFβ1 is not… read more here.
Keywords: fibrosis; vitro vivo; inhibiting fak; fak akt ... See more keywords
CXCL1 from tumor-associated lymphatic endothelial cells drives gastric cancer cell into lymphatic system via activating integrin β1/FAK/AKT signaling.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2016.10.043
Abstract: Crosstalk between lymphatic endothelial cells (LECs) and tumor cells in the tumor microenvironment plays a crucial role in tumor metastasis. Our previous study indicated chemokine (C-X-C motif) ligand 1 (CXCL1) from LECs stimulates the metastasis… read more here.
Keywords: cxcl1; gastric cancer; integrin fak; fak akt ... See more keywords
Integrin αvβ6 contributes to the development of intestinal fibrosis via the FAK/AKT signaling pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2021.113003
Abstract: Intestinal fibrosis is one of the most severe complications of inflammatory bowel disease (IBD) and frequently requires surgery due to intestinal obstruction. Integrin αvβ6, which is mainly regulated by the integrin β6 subunit gene (ITGB6),… read more here.
Keywords: development; mice; fak akt; intestinal fibrosis ... See more keywords
Long non-coding RNA AC018926.2 regulates palmitic acid exposure-compromised osteogenic potential of periodontal ligament stem cells via the ITGA2/FAK/AKT pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Cell proliferation"
DOI: 10.1111/cpr.13411
Abstract: Although obesity has been proposed as a risk factor for periodontitis, the influence of excessive fat accumulation on the development of periodontitis and periodontal recovery from disease remains largely unknown. This study investigated the cellular… read more here.
Keywords: itga2 fak; itga2; fak akt; acid ... See more keywords
Disintegrin tablysin-15 suppresses cancer hallmarks in melanoma cells by blocking FAK/Akt/ERK and NF-κB signaling.
Sign Up to like & getrecommendations! Published in 2019 at "Current cancer drug targets"
DOI: 10.2174/1568009620666200101094736
Abstract: BACKGROUND Integrinsarecrucial anti-cancer therapy targets. We previously showed that tablysin-15 is an integrin antagonist via its Arg-Gly-Asp motif in a novel structural context. OBJECTIVE Here we investigated the anti-cancer effectsand mechanisms of action of tablysin-15… read more here.
Keywords: blocking fak; akt erk; fak akt; melanoma cells ... See more keywords
Extracellular Vesicle-Derived miR-105-5p Promotes Malignant Phenotypes of Esophageal Squamous Cell Carcinoma by Targeting SPARCL1 via FAK/AKT Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.819699
Abstract: Objective: Esophageal squamous cell carcinoma (ESCC) presents high morbidity and mortality. It was demonstrated that blood-derived vesicles can facilitate ESCC development and transmit regulating signals. However, the molecular mechanism of vesicle miRNA secreted by tumor… read more here.
Keywords: cell; signaling pathway; mirna 105; akt signaling ... See more keywords
Induction of Apoptosis and Effect on the FAK/AKT/mTOR Signal Pathway by Evodiamine in Gastric Cancer Cells
Sign Up to like & getrecommendations! Published in 2022 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb44090298
Abstract: Evodiamine isolated from Evodia rutaecarpa has been known to have anti-tumor activity against various cancer cell types. Although there have been reports showing the inhibitory effect of evodiamine on cell survival of gastric cancer cell,… read more here.
Keywords: evodiamine; cancer; apoptosis; fak akt ... See more keywords
Suppressing Cdk5 Activity by Luteolin Inhibits MPP+-Induced Apoptotic of Neuroblastoma through Erk/Drp1 and Fak/Akt/GSK3β Pathways
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26051307
Abstract: Parkinson’s disease (PD) is characterized by the progressive degeneration of dopaminergic neurons. The cause of PD is still unclear. Oxidative stress and mitochondrial dysfunction have been linked to the development of PD. Luteolin, a non-toxic… read more here.
Keywords: drp1 fak; fak akt; akt gsk3;
GSK‑3β inhibition promotes doxorubicin‑induced apoptosis in human cholangiocarcinoma cells via FAK/AKT inhibition.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular medicine reports"
DOI: 10.3892/mmr.2020.11502
Abstract: Cholangiocarcinoma (CCA) is the most common type of malignant tumor of the bile duct and is characterized by high morbidity and mortality; it is difficult to diagnose in the early stages and responds poorly to… read more here.
Keywords: induced apoptosis; fak akt; inhibition; cca ... See more keywords