Development of resistance to FAK inhibition in pancreatic cancer is linked to stromal depletion
Sign Up to like & getrecommendations! Published in 2019 at "Gut"
DOI: 10.1136/gutjnl-2018-317424
Abstract: Objective We investigated how pancreatic cancer developed resistance to focal adhesion kinase (FAK) inhibition over time. Design Pancreatic ductal adenocarcinoma (PDAC) tumours from KPC mice (p48-CRE; LSL-KRasG12D/wt; p53flox/wt) treated with FAK inhibitor were analysed for… read more here.
Keywords: fak inhibition; fak inhibitor; pancreatic cancer;