Development of resistance to FAK inhibition in pancreatic cancer is linked to stromal depletion
Sign Up to like & getrecommendations! Published in 2019 at "Gut"
DOI: 10.1136/gutjnl-2018-317424
Abstract: Objective We investigated how pancreatic cancer developed resistance to focal adhesion kinase (FAK) inhibition over time. Design Pancreatic ductal adenocarcinoma (PDAC) tumours from KPC mice (p48-CRE; LSL-KRasG12D/wt; p53flox/wt) treated with FAK inhibitor were analysed for… read more here.
Keywords: fak inhibition; fak inhibitor; pancreatic cancer;
A FAK Inhibitor Boosts Anti-PD1 Immunotherapy in a Hepatocellular Carcinoma Mouse Model
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DOI: 10.3389/fphar.2021.820446
Abstract: Anti-PD-1/PD-L1 immunotherapy has limited efficacy in hepatocellular carcinoma (HCC) and does not benefit all patients. A FAK inhibitor (VS-4718) has been reported to improve the microenvironment in some tumors. This study aimed to investigate the… read more here.
Keywords: hcc; vs4718; fak inhibitor; anti pd1 ... See more keywords
FAK Inhibitor-Based Combinations with MEK or PKC Inhibitors Trigger Synergistic Antitumor Effects in Uveal Melanoma
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DOI: 10.3390/cancers15082280
Abstract: Simple Summary Uveal Melanoma (UM) is a rare and malignant intraocular tumor with dismal prognosis. Despite efficient control of the primary tumor by radiation or surgery, up to 50% of patients subsequently develop metastases, mainly… read more here.
Keywords: fak; fak inhibitor; mek; pkc inhibitors ... See more keywords
The Role of E-Cadherin and microRNA on FAK Inhibitor Response in Malignant Pleural Mesothelioma (MPM)
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DOI: 10.3390/ijms221910225
Abstract: Malignant pleural mesothelioma (MPM) is an aggressive malignancy with limited effective treatment options. Focal adhesion kinase (FAK) inhibitors have been shown to efficiently suppress MPM cell growth initially, with limited utility in the current clinical… read more here.
Keywords: mpm; fak inhibitor; malignant pleural; mpm cells ... See more keywords