Non-redundant functions of FAK and Pyk2 in intestinal epithelial repair
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-41116-1
Abstract: Adhesion signaling between epithelial cells and the extracellular matrix plays a critical role in maintaining tissue homeostasis and the response to tissue damage. Focal adhesion kinase (FAK) and its close relative Pyk2 are non-receptor tyrosine… read more here.
Keywords: non redundant; epithelial repair; redundant functions; colitis ... See more keywords
PYK2 is overexpressed in chronic lymphocytic leukaemia: A potential new therapeutic target
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17688
Abstract: Chronic Lymphocytic Leukaemia (CLL) is the most common adult B‐cell leukaemia and despite improvement in patients' outcome, following the use of targeted therapies, it remains incurable. CLL supportive microenvironment plays a key role in both… read more here.
Keywords: pyk2; cll; lymphocytic leukaemia; fak pyk2 ... See more keywords
Endogenous Control Mechanisms of FAK and PYK2 and Their Relevance to Cancer Development
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DOI: 10.3390/cancers10060196
Abstract: Focal adhesion kinase (FAK) and its close paralogue, proline-rich tyrosine kinase 2 (PYK2), are key regulators of aggressive spreading and metastasis of cancer cells. While targeted small-molecule inhibitors of FAK and PYK2 have been found… read more here.
Keywords: kinase; control; fak pyk2; cancer cells ... See more keywords