Aberrant upregulation of KLK10 promotes metastasis via enhancement of EMT and FAK/SRC/ERK axis in PDAC.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.03.194
Abstract: Pancreatic Ductal Adenocarcinoma (PADC) metastasis is the leading cause of morality of this severe malignant tumor. Proteases are key players in the degradation of extracellular matrix which promotes the cascade of tumor metastasis. As a… read more here.
Keywords: src erk; klk10; pdac; fak src ... See more keywords
Expression regulation of cold-inducible protein RBM3 by FAK/Src signaling for neuroprotection against rotenone under mild hypothermia.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.11.105
Abstract: Mild hypothermia is a well-established technique for alleviating neurological injuries in clinical surgery. RNA-binding protein motif 3 (RBM3) has been identified as a crucial factor in mediating hypothermic neuroprotection, providing its induction as a promising… read more here.
Keywords: rbm3; hypothermia; mild hypothermia; fak src ... See more keywords
EGFR/FAK and c-Src signaling pathways mediate the internalization of Staphylococcus aureus by osteoblasts.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular microbiology"
DOI: 10.1111/cmi.13240
Abstract: Internalization of Staphylococcus aureus (S. aureus) in osteoblasts plays a critical role in the persistence and recurrence of osteomyelitis, the mechanisms involved in this process remain largely unknown. In the present study, evidence of internalized… read more here.
Keywords: egfr fak; internalization; aureus; fak src ... See more keywords
Abstract 4889: Blockade of FAK and Src activation enhances antitumor activity of sorafenib in non-small cell lung carcinomas harboring G12S KRAS mutation
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-4889
Abstract: Background: Mutations in the KRAS gene are present in approximately 25% of lung adenocarcinoma cases and are associated with poor prognosis and resistance to anti-EGFR therapy. Although sorafenib has shown considerable promise in the treatment… read more here.
Keywords: g12s kras; kras mutation; fak; fak src ... See more keywords
MMP-11 promoted the oral cancer migration and FAK/Src activation
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.15824
Abstract: Matrix metalloproteinase-11 (MMP-11) has been observed in most invasive human carcinomas. The current study investigated the association between the clinicopathological characteristics and MMP-11 expression in oral squamous cell carcinoma (OSCC) patients. Immunohistochemistry (IHC) staining was… read more here.
Keywords: mmp expression; fak src; mmp; migration ... See more keywords
Expression and Clinical Significance of Concomitant FAK/SRC and p-Paxillin in Mobile Tongue Squamous Cell Carcinoma.
Sign Up to like & getrecommendations! Published in 2017 at "Anticancer research"
DOI: 10.21873/anticanres.11449
Abstract: BACKGROUND/AIM The focal adhesion kinase (FAK)/SRC phosphorylation cascade and its downstream target paxillin have been implicated in malignant transformation, tumor growth and progression, together with metastasis. The present study aimed to evaluate the clinical significance… read more here.
Keywords: expression; paxillin; fak src; mobile tongue ... See more keywords
Cyclin G2 Inhibits Oral Squamous Cell Carcinoma Growth and Metastasis by Binding to IGFBP3 and Regulating the FAK-SRC-STAT Signaling Pathway
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.560572
Abstract: The cell cycle protein cyclin G2 is considered a tumor suppressor. However, its regulatory effects and potential mechanisms in oral cancers are not well understood. This study aimed to investigate the effect of cyclin G2… read more here.
Keywords: cell; fak src; cyclin; metastasis ... See more keywords
Cortactin Is Required for Efficient FAK, Src and Abl Tyrosine Kinase Activation and Phosphorylation of Helicobacter pylori CagA
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22116045
Abstract: Cortactin is a well-known regulatory protein of the host actin cytoskeleton and represents an attractive target of microbial pathogens like Helicobacter pylori. H. pylori manipulates cortactin’s phosphorylation status by type-IV secretion-dependent injection of its virulence… read more here.
Keywords: src abl; fak src; tyrosine; cortactin ... See more keywords
A Triazaspirane Derivative Inhibits Migration and Invasion in PC3 Prostate Cancer Cells
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28114524
Abstract: Cancer is a serious health problem due to the complexity of establishing an effective treatment. The purpose of this work was to evaluate the activity of a triazaspirane as a migration and invasion inhibitor in… read more here.
Keywords: migration invasion; pc3; fak src; migration ... See more keywords