Design, Synthesis, and Evaluation of Highly Potent FAK-Targeting PROTACs.
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DOI: 10.1021/acsmedchemlett.9b00372
Abstract: Focal adhesion kinase (FAK), a cytoplasmic protein tyrosine kinase, exerts kinase-dependent enzymatic functions and kinase-independent scaffolding functions, both of which are crucial in cancer development, early embryonic development, and reproduction. However, previous efforts for FAK… read more here.
Keywords: highly potent; design synthesis; fak; evaluation highly ... See more keywords