A Plasmodium falciparum protein tyrosine phosphatase inhibitor identified from the ChEMBL‐NTD database blocks parasite growth
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13171
Abstract: Post‐translational modifications, especially reversible phosphorylation, are among the most common mechanisms that regulate protein function and biological processes in Plasmodium species. Of the Plasmodium phosphatases, phosphatase of regenerating liver (PfPRL) is secreted and is an… read more here.
Keywords: phosphatase; inhibitor; falciparum; parasite growth ... See more keywords
Fluorene‐Chloroquine Hybrids: Synthesis, in vitro Antiplasmodial Activity, and Inhibition of Heme Detoxification Machinery of Plasmodium falciparum
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DOI: 10.1002/cmdc.202200414
Abstract: Fluorene‐chloroquine hybrids have been identified as a new promising class of antiplasmodial agents. The most active compound 9 d exhibited good in vitro antiplasmodial activity against a chloroquine‐sensitive NF54 strain of the human malaria parasite Plasmodium falciparum… read more here.
Keywords: inhibition; heme; fluorene chloroquine; chloroquine hybrids ... See more keywords
Centromere and its associated proteins—what we know about them in Plasmodium falciparum
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DOI: 10.1002/iub.1878
Abstract: The complex life cycle of intracellular parasitic protozoans entails multiple rounds of DNA replication and mitosis followed by cytokinesis to release daughter parasites. To gain insights into mitotic events it is imperative to identify the… read more here.
Keywords: centromere associated; associated proteins; falciparum; plasmodium falciparum ... See more keywords
Five years following first detection of Anopheles stephensi (Diptera: Culicidae) in Djibouti, Horn of Africa: populations established—malaria emerging
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DOI: 10.1007/s00436-019-06213-0
Abstract: The Asian malaria mosquito, Anopheles stephensi, is a well-known and important vector of Plasmodium falciparum and P. vivax. Until 2013, its geographical distribution was confined to central and southern Asia including the Arabian Peninsula. In… read more here.
Keywords: malaria; falciparum; falciparum vivax; anopheles stephensi ... See more keywords
Depletion of cholesterol could be associated with modulation of progesterone but not other sex hormone levels during Plasmodium falciparum infection in humans: a cross-sectional study from Zaria, Nigeria.
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DOI: 10.1007/s00436-020-06826-w
Abstract: In order for Plasmodium falciparum to grow and survive in its host, membrane biogenesis, fueled by host cholesterol, is essential for these processes. Consistent with this essential role, more insights into the cholesterol pathway would… read more here.
Keywords: falciparum; cholesterol; study; falciparum infected ... See more keywords
Erythrocyte membrane proteins involved in the immune response to Plasmodium falciparum and Plasmodium vivax infection.
Sign Up to like & getrecommendations! Published in 2021 at "Parasitology research"
DOI: 10.1007/s00436-021-07135-6
Abstract: Invasion of Plasmodium into the red blood cell involves the interactions of a substantial number of proteins, with red cell membrane proteins as the most involved throughout the process from entry to exit. The objective… read more here.
Keywords: membrane proteins; response; falciparum; infection ... See more keywords
Heterogeneity in the acquisition of naturally acquired antibodies to cell-traversal protein for ookinetes and sporozoites (CelTOS) and thrombospondin-related adhesion protein (TRAP) of Plasmodium falciparum in naturally infected patients from unstable malaria areas in Iran.
Sign Up to like & getrecommendations! Published in 2019 at "Acta tropica"
DOI: 10.1016/j.actatropica.2018.12.014
Abstract: Currently, there is no subunit malaria vaccine capable of providing long-lasting protection, and a vaccine based on a single-antigen has shown moderate to unsatisfactory efficacies in clinical trials. As in malaria elimination and eradication strategies,… read more here.
Keywords: protein; cell traversal; falciparum; pfceltos pftrap ... See more keywords
Acquisition of naturally acquired antibody response to Plasmodium falciparum erythrocyte membrane protein 1-DBLα and differential regulation of IgG subclasses in severe and uncomplicated malaria
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DOI: 10.1016/j.apjtb.2017.09.017
Abstract: Abstract Objectives To explore whether individuals infected with Plasmodium falciparum (P. falciparum) develop antibodies directed against PfEMP1-DBLα, and to assess their IgG subclass distribution in severe and uncomplicated malaria. Methods The anti-PfDBLα IgG and their IgG… read more here.
Keywords: igg; falciparum; igg subclasses; severe uncomplicated ... See more keywords
Homozygosity for the CD1E*02 allele is associated with a resistance to Plasmodium falciparum malaria infection in Gabonese school children.
Sign Up to like & getrecommendations! Published in 2017 at "Asian Pacific journal of tropical medicine"
DOI: 10.1016/j.apjtm.2017.01.017
Abstract: OBJECTIVE To explore the possible association between polymorphisms in CD1 genes and both asymptomatic and mild Plasmodium falciparum infection. METHODS Two clusters of 85 school children, from the village of Dienga (Gabon) were investigated. The… read more here.
Keywords: school children; falciparum; infection; plasmodium falciparum ... See more keywords
Covalent inhibition of P. falciparum ferredoxin-NADP+ reductase: Exploring alternative strategies for the development of new antimalarial drugs.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.09.008
Abstract: The protozoan Plasmodium falciparum is the main aetiological agent of tropical malaria. Characteristic of the phylum is the presence of a plastid-like organelle which hosts several homologs of plant proteins, including a ferredoxin (PfFd) and… read more here.
Keywords: ferredoxin; reductase; covalent inhibition; falciparum ... See more keywords
TLR8 is activated by 5'-methylthioinosine, a Plasmodium falciparum-derived intermediate of the purine salvage pathway.
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DOI: 10.1016/j.celrep.2022.110691
Abstract: The innate immune recognition of the malaria-causing pathogen Plasmodium falciparum (P. falciparum) is not fully explored. Here, we identify the nucleoside 5'-methylthioinosine (MTI), a Plasmodium-specific intermediate of the purine salvage pathway, as a pathogen-derived Toll-like receptor… read more here.
Keywords: plasmodium; intermediate purine; purine salvage; salvage pathway ... See more keywords