Rational Optimization of Dihydropyrimidinone‐Quinoline Hybrids as Plasmodium falciparum Glutathione Reductase Inhibitors
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DOI: 10.1002/cmdc.202200034
Abstract: A series of dihydropyrimidinone‐based antimalarial compounds were designed and synthesised based on the previously identified amide‐based quinoline hybrids which showed good resistance reversal ability against the resistant strain of Plasmodium falciparum. The aromatic ring on… read more here.
Keywords: plasmodium falciparum; glutathione reductase; dihydropyrimidinone; falciparum glutathione ... See more keywords