Malaria surveys using rapid diagnostic tests and validation of results using post hoc quantification of Plasmodium falciparum histidine-rich protein 2
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DOI: 10.1186/s12936-017-2101-8
Abstract: BackgroundRapid diagnostic test (RDT) positivity is supplanting microscopy as the standard measure of malaria burden at the population level. However, there is currently no standard for externally validating RDT results from field surveys.MethodsIndividuals’ blood concentration… read more here.
Keywords: rdt positivity; protein; falciparum histidine; rdt ... See more keywords
A new highly sensitive enzyme-linked immunosorbent assay for the detection of Plasmodium falciparum histidine-rich protein 2 in whole blood
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DOI: 10.1186/s12936-018-2545-5
Abstract: BackgroundThe detection of submicroscopic infections in low prevalence settings has become an increasingly important challenge for malaria elimination strategies. The current field rapid diagnostic tests (RDTs) for Plasmodium falciparum malaria are inadequate to detect low-density… read more here.
Keywords: falciparum; falciparum histidine; highly sensitive; plasmodium falciparum ... See more keywords
Plasmodium falciparum histidine-rich protein 2 diversity in Ghana
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DOI: 10.1186/s12936-020-03328-z
Abstract: In the absence of microscopy, Plasmodium falciparum histidine-rich proteins 2 (PfHRP2)-based rapid diagnostic tests (RDTs) are recommended for the diagnosis of falciparum malaria, particularly in endemic regions. However, genetic variability of the pfhrp2 gene threatens… read more here.
Keywords: diversity; microscopy; falciparum; falciparum histidine ... See more keywords