Depletion of cholesterol could be associated with modulation of progesterone but not other sex hormone levels during Plasmodium falciparum infection in humans: a cross-sectional study from Zaria, Nigeria.
Sign Up to like & getrecommendations! Published in 2020 at "Parasitology research"
DOI: 10.1007/s00436-020-06826-w
Abstract: In order for Plasmodium falciparum to grow and survive in its host, membrane biogenesis, fueled by host cholesterol, is essential for these processes. Consistent with this essential role, more insights into the cholesterol pathway would… read more here.
Keywords: falciparum; cholesterol; study; falciparum infected ... See more keywords
Nanofocused Scanning X‑ray Fluorescence MicroscopyRevealing an Effect of Heterozygous Hemoglobin S and C on BiochemicalActivities in Plasmodium falciparum-Infected Erythrocytes
Sign Up to like & getrecommendations! Published in 2020 at "Analytical Chemistry"
DOI: 10.1021/acs.analchem.9b05111.s001
Abstract: While there is ample evidence suggesting that carriers of heterozygous hemoglobin S and C are protected from life-threatening malaria, little is known about the underlying biochemical mechanisms at the single cell level. Using nanofocused scanning… read more here.
Keywords: hemoglobin; ray fluorescence; falciparum infected; infected erythrocytes ... See more keywords
Plasma biomarkers of hemoglobin loss in Plasmodium falciparum-infected children identified by quantitative proteomics.
Sign Up to like & getrecommendations! Published in 2021 at "Blood"
DOI: 10.1182/blood.2021014045
Abstract: Anemia is common among young children infected with Plasmodium falciparum (Pf) and severe malarial anemia (SMA) is a major cause of their mortality. Two major mechanisms cause malarial anemia: hemolysis of uninfected as well as… read more here.
Keywords: plasmodium falciparum; hemoglobin; falciparum infected; infected children ... See more keywords
Stabilization of RDT target antigens present in dried Plasmodium falciparum-infected samples for validating malaria rapid diagnostic tests at the point of care
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DOI: 10.1186/s12936-017-2155-7
Abstract: BackgroundMalaria rapid diagnostic tests (RDTs) are a great achievement in implementation of parasite based diagnosis as recommended by World Health Organization. A major drawback of RDTs is lack of positive controls to validate different batches/lots… read more here.
Keywords: target antigens; rdt target; falciparum infected; infected samples ... See more keywords
Human plasma plasminogen internalization route in Plasmodium falciparum-infected erythrocytes
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DOI: 10.1186/s12936-020-03377-4
Abstract: The intra-erythrocytic development of the malaria parasite Plasmodium falciparum depends on the uptake of a number of essential nutrients from the host cell and blood plasma. It is widely recognized that the parasite imports low… read more here.
Keywords: plasma; plasminogen; falciparum infected; plasmodium falciparum ... See more keywords
Blood outgrowth endothelial cells (BOECs) as a novel tool for studying adhesion of Plasmodium falciparum-infected erythrocytes
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0204177
Abstract: The lack of suitable animal models for the study of cytoadhesion of P. falciparum-infected erythrocytes (IEs) has necessitated in vitro studies employing a range of cell lines of either human tumour origin (e.g., BeWo and… read more here.
Keywords: adhesion; falciparum infected; infected erythrocytes; endothelial cells ... See more keywords
Human TLR8 Senses RNA From Plasmodium falciparum-Infected Red Blood Cells Which Is Uniquely Required for the IFN-γ Response in NK Cells
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.00371
Abstract: During blood-stage malaria, the innate immune system initiates the production of pro-inflammatory cytokines, including IFN-γ, that are critical to host defense and responsible for severe disease. Nonetheless, the innate immune pathways activated during this process… read more here.
Keywords: immune; tlr8; infected red; plasmodium falciparum ... See more keywords