The pan‐cancer analysis of the oncogenic role of FAM72A as a BRCA prognostic biomarker and immunotherapeutic target
Sign Up to like & getrecommendations! Published in 2023 at "Environmental Toxicology"
DOI: 10.1002/tox.23751
Abstract: In this study, we first comprehensively investigated the expression profile, mutation status, and survival analysis of FAM72A as well as the correlation between FAM72A and DNA damage repair, methylation, and cell stemness analysis using bioinformatics… read more here.
Keywords: cell; fam72a; analysis; role fam72a ... See more keywords
Fam72a enforces error-prone DNA repair during antibody diversification.
Sign Up to like & getrecommendations! Published in 2021 at "Nature"
DOI: 10.1038/s41586-021-04093-y
Abstract: Efficient humoral responses rely on DNA damage, mutagenesis and error-prone DNA repair. Diversification of B cell receptors through somatic hypermutation and class-switch recombination are initiated by cytidine deamination in DNA mediated by activation-induced cytidine deaminase (AID)1… read more here.
Keywords: prone dna; dna repair; dna; fam72a ... See more keywords
Integrated systemic analysis of FAM72A to identify its clinical relevance, biological function, and relationship to drug sensitivity in hepatocellular carcinoma
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DOI: 10.3389/fonc.2022.1046473
Abstract: Background The family with sequence similarity 72 member A (FAM72A) protein has been identified as an effector of multiple pathological processes in many cancers. The value of FAM72A in HCC remains largely unknown. Methods Data… read more here.
Keywords: hcc; drug sensitivity; expression; fam72a ... See more keywords
Prognostic and Immunological Implications of FAM72A in Pan-Cancer and Functional Validations
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DOI: 10.3390/ijms24010375
Abstract: The family with sequence similarity 72 Member A (FAM72A) is overexpressed in several types of cancer. However, its contributions to tumorigenesis remain largely unknown. Based on The Cancer Genome Atlas (TCGA) database, FAM72A was upregulated… read more here.
Keywords: fam72a pan; fam72a; prognostic immunological; implications fam72a ... See more keywords