Reduced expression of alanyl aminopeptidase is a robust biomarker of non‐familial adenomatous polyposis and non‐hereditary nonpolyposis colorectal cancer syndrome early‐onset colorectal cancer
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DOI: 10.1002/cam4.5675
Abstract: Early‐onset colorectal cancer (EOCRC) has been increasing in incidence worldwide but its genomic pathogenesis is mostly undetermined. This study aimed to identify robust EOCRC‐specific gene expression patterns in non‐familial adenomatous polyposis (FAP) and non‐hereditary nonpolyposis… read more here.
Keywords: early onset; colorectal cancer; non familial; onset colorectal ... See more keywords
Genetic alteration of colorectal adenoma‐carcinoma sequence among gastric adenocarcinoma and dysplastic lesions in a patient with attenuated familial adenomatous polyposis
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DOI: 10.1002/mgg3.1348
Abstract: Familial adenomatous polyposis (FAP) is characterized by colorectal polyposis and adenocarcinoma that is frequently accompanied by extracolonic neoplasm. The risk of gastric carcinoma is increasing in Western FAP patients as well as Asian patients. read more here.
Keywords: carcinoma; familial adenomatous; genetic alteration; adenocarcinoma ... See more keywords
A novel large germ line deletion in adenomatous polyposis coli (APC) gene associated with familial adenomatous polyposis
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DOI: 10.1002/mgg3.479
Abstract: Familial adenomatous polyposis (FAP) is a familial colorectal cancer predisposition syndrome characterized by the development of numerous colorectal polyps, which is inherited in an autosomal dominant manner. FAP is caused by germ line mutations in… read more here.
Keywords: germ line; apc gene; familial adenomatous; polyposis ... See more keywords
Burkitt-like lymphoma in a pediatric patient with familial adenomatous polyposis.
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DOI: 10.1016/j.cancergen.2019.09.001
Abstract: Familial adenomatous polyposis (FAP) is an autosomal dominant condition that predisposes to multiple malignancies, most commonly colorectal carcinoma, but has rarely been associated with lymphoma. We discuss one patient found to have Burkitt-like Lymphoma (BLL)… read more here.
Keywords: burkitt like; adenomatous polyposis; familial adenomatous; like lymphoma ... See more keywords
Necessity of multiplex ligation probe amplification in genetic tests: Germline variant analysis of the APC gene in familial adenomatous polyposis patients.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer genetics"
DOI: 10.1016/j.cancergen.2022.02.002
Abstract: BACKGROUND Familial adenomatous polyposis (FAP) is an autosomal dominant hereditary cancer syndrome characterized by hundreds to thousands of colorectal adenomatous polyps. Without treatment, progression to colorectal cancer is inevitable. Most pathogenic mutations in the APC… read more here.
Keywords: adenomatous polyposis; probe amplification; familial adenomatous; multiplex ligation ... See more keywords
Upper GI involvement in children with familial adenomatous polyposis syndrome: single-center experience and meta-analysis of the literature.
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DOI: 10.1016/j.gie.2017.10.043
Abstract: BACKGROUND AND AIMS Familial adenomatous polyposis (FAP) is a hereditary syndrome that can affect the entire GI tract. Current screening recommendations include EGD starting at age 25 to 30 years or earlier in symptomatic patients.… read more here.
Keywords: children fap; involvement children; familial adenomatous; upper involvement ... See more keywords
Fertility preservation and PGT-M in women with familial adenomatous polyposis-associated desmoid tumours.
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DOI: 10.1016/j.rbmo.2021.07.010
Abstract: RESEARCH QUESTION Is ovarian stimulation and pregnancy in women with familial adenomatous polyposis (FAP)-associated desmoid tumours safe? DESIGN The study included women with FAP-associated desmoid tumours who underwent fertility treatments at the authors' tertiary medical… read more here.
Keywords: associated desmoid; familial adenomatous; number; women familial ... See more keywords
A novel pathogenic single nucleotide germline deletion in APC gene in a four generation Chinese family with familial adenomatous polyposis
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DOI: 10.1038/s41598-017-10395-x
Abstract: Familial adenomatous polyposis (FAP) is an autosomal dominant precancerous condition which is associated with germline mutations of the APC gene. Clinically, FAP is characterized by the development of multiple colorectal adenomas or polyps which finally… read more here.
Keywords: apc gene; familial adenomatous; family; generation ... See more keywords
Efficacy and safety of intensive downstaging polypectomy (IDP) for multiple duodenal adenomas in patients with familial adenomatous polyposis: a prospective cohort study
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DOI: 10.1055/a-1983-5963
Abstract: BACKGROUND AND STUDY AIMS Patients with familial adenomatous polyposis (FAP) risk developing multiple duodenal adenomas (MDAs), leading to duodenal cancer and death. We investigated the safety and efficacy of intensive endoscopic intervention for MDAs integrated… read more here.
Keywords: adenomatous polyposis; duodenal adenomas; patients familial; multiple duodenal ... See more keywords
Is there a role for endoscopic management of the large bowel in familial adenomatous polyposis?
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DOI: 10.1055/a-1990-1046
Abstract: endoscopic downstaging of colorectal polyp burden in patients with familial adenomatous polyposis (FAP) in a multicenter, prospective, interventional study. After 5 years, 90.4% of patients with intact colon remained without surgical intervention and 83.9% of… read more here.
Keywords: endoscopic; adenomatous polyposis; management; large bowel ... See more keywords
Endoscopic papillectomy for ampullary lesions in patients with familial adenomatous polyposis compared with sporadic lesions: a propensity score-matched cohort
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DOI: 10.1055/a-2029-2935
Abstract: BACKGROUND Familial-adenomatous-polyposis (FAP) is a rare inherited cancer predisposition syndrome. The treatment for FAP-related ampullary lesions (AL) is challenging and the role of endoscopic papillectomy (EP) is not elucidated yet. Data of FAP associated AL… read more here.
Keywords: propensity score; ampullary lesions; familial adenomatous; fap patients ... See more keywords