Computational Study of Amyloidβ42 Familial Mutations and Metal Interaction: Impact on Monomers and Aggregates Dynamical Behaviors
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DOI: 10.1021/acs.inorgchem.3c04555
Abstract: One of the main hallmarks of Alzheimer’s Disease is the formation of β-amyloid plaques, whose formation may be enhanced by metal binding or the appearance of familial mutations. In the present study, the simultaneous effect… read more here.
Keywords: computational study; study amyloid; familial mutations; metal binding ... See more keywords
On the role of sidechain size and charge in the aggregation of Aβ42 with familial mutations
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1803539115
Abstract: Significance The aggregation of the amyloid-β (Aβ) peptide into amyloid fibrils is associated with Alzheimer’s disease, and several point mutations leading to early-onset disease have been identified in Aβ. By studying the aggregation of five… read more here.
Keywords: aggregation; alzheimer disease; charge; disease ... See more keywords