Abstract 3366: APOBEC3 family of cytidine deaminases in sensitizing triple-negative breast cancer cells to cisplatin and carboplatin
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DOI: 10.1158/1538-7445.am2018-3366
Abstract: Cisplatin is a DNA damaging chemotherapeutic which forms interstrand crosslinks (ICL) and intrastrand adducts that induce replication fork collapse and lead to apoptosis. These adduct sites can be repaired through several repair pathways, the most… read more here.
Keywords: cancer; cisplatin carboplatin; cytidine deaminases; family cytidine ... See more keywords