Identification of a broadly conserved family of enzymes that hydrolyze (p)ppApp.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2213771120
Abstract: Bacteria produce a variety of nucleotide second messengers to adapt to their surroundings. Although chemically similar, the nucleotides guanosine penta- and tetraphosphate [(p)ppGpp] and adenosine penta- and tetraphosphate [(p)ppApp] have distinct functions in bacteria. (p)ppGpp… read more here.
Keywords: hydrolyze ppapp; family; identification broadly; ppapp hydrolases ... See more keywords
TET2 in Normal and Malignant Hematopoiesis.
Sign Up to like & getrecommendations! Published in 2017 at "Cold Spring Harbor perspectives in medicine"
DOI: 10.1101/cshperspect.a026518
Abstract: The ten-eleven translocation (TET) family of enzymes were originally cloned from the translocation breakpoint of t(10;11) in infant acute myeloid leukemia (AML) with subsequent genomic analyses revealing somatic mutations and suppressed expression of TET family… read more here.
Keywords: hematopoiesis; tet family; tet2 normal; normal malignant ... See more keywords