Dysregulation of the TET family of epigenetic regulators in hematopoietic malignancies.
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DOI: 10.1182/blood.2019791475
Abstract: DNA methylation has pivotal regulatory roles in mammalian development, retrotransposon silencing, genomic imprinting, X-chromosome inactivation and cancer. Cancer cells display highly dysregulated DNA methylation profiles characterized by global hypomethylation in conjunction with hypermethylation of promoter… read more here.
Keywords: epigenetic regulators; tet family; family epigenetic; dysregulation tet ... See more keywords