EGFR family and Src family kinase interactions: mechanics matters?
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in cell biology"
DOI: 10.1016/j.ceb.2017.12.003
Abstract: Receptor tyrosine kinases (RTKs), such as the EGF receptor family, and adhesion molecules, such as integrins, have historically been viewed to have distinctly separable roles in the cell. In this classical view, integrins mediate mechanical… read more here.
Keywords: egfr family; family src; family; src family ... See more keywords
Remodeling of HIV-1 Nef Structure by Src-Family Kinase Binding.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2017.12.008
Abstract: The HIV-1 accessory protein Nef controls multiple aspects of the viral life cycle and host immune response, making it an attractive therapeutic target. Previous X-ray crystal structures of Nef in complex with key host cell… read more here.
Keywords: src family; family kinase; sh3 sh2; family ... See more keywords
A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase.
Sign Up to like & getrecommendations! Published in 2021 at "Nature communications"
DOI: 10.1038/s41467-021-26390-w
Abstract: The fungus Candida albicans is an opportunistic pathogen that can exploit imbalances in microbiome composition to invade its human host, causing pathologies ranging from vaginal candidiasis to fungal sepsis. Bacteria of the genus Lactobacillus are… read more here.
Keywords: small molecule; candida albicans; family kinase; lactobacillus species ... See more keywords
Anti-allergic effect of the Src family kinase inhibitor saracatinib.
Sign Up to like & getrecommendations! Published in 2020 at "Die Pharmazie"
DOI: 10.1691/ph.2020.9949
Abstract: The aim of this study was to evaluate the anti-anaphylactic and anti-allergic potentials of saracatinib, a Src family kinase inhibitor that was already shown to be safe in clinical trials when it was used as… read more here.
Keywords: src family; kinase inhibitor; saracatinib; family kinase ... See more keywords