CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function
Sign Up to like & getrecommendations! Published in 2018 at "Cell Reports"
DOI: 10.1016/j.celrep.2017.12.083
Abstract: Summary Various kinases, including a cyclin-dependent kinase (CDK) family member, regulate the growth and functions of primary cilia, which perform essential roles in signaling and development. Neurological disorders linked to CDK-Like (CDKL) proteins suggest that… read more here.
Keywords: evolved distinct; cilium length; family; cdkl family ... See more keywords
In depth analysis of kinase cross screening data to identify chemical starting points for inhibition of the Nek family of kinases.
Sign Up to like & getrecommendations! Published in 2018 at "MedChemComm"
DOI: 10.1039/c7md00510e
Abstract: Potent, selective, and cell active small molecule kinase inhibitors are useful tools to help unravel the complexities of kinase signaling. As the biological functions of individual kinases become better understood, they can become targets of… read more here.
Keywords: nek family; kinase; starting points; chemical starting ... See more keywords
Induction of the NEK family of kinases in the lungs of mice subjected to cecal ligation and puncture model of sepsis.
Sign Up to like & getrecommendations! Published in 2021 at "Tissue barriers"
DOI: 10.1080/21688370.2021.1929787
Abstract: Endothelial barrier dysfunction (EBD) is the hallmark of Acute Respiratory Distress Syndrome (ARDS), a potentially lethal respiratory disorder associated with the COVID-19 - related deaths. Herein, we employed a cecal ligation and puncture (CLP) murine… read more here.
Keywords: sepsis; cecal ligation; ligation puncture; model sepsis ... See more keywords
SAT0009 Tyrosine kinase pathways in monosodium-urate crystal-induced inflammatory responses
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.5172
Abstract: Background Deposition of monosodium urate (MSU) crystals in the joints or other tissues is a hallmark in the pathogenesis of gout. The urate crystal-induced inflammation is known to be mediated mainly by neutrophils besides monocytes… read more here.
Keywords: crystal induced; src family; crystal; family kinases ... See more keywords
Src-family kinases activation in spinal microglia contributes to central sensitization and chronic pain after lumbar disc herniation
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Pain"
DOI: 10.1177/1744806917733637
Abstract: Background Lumbar disc herniation is a major cause of radicular pain, but the underlying mechanisms remain largely unknown. Spinal activation of src-family kinases are involved in the development of chronic pain from nerve injury, inflammation,… read more here.
Keywords: lumbar disc; src family; family kinases; disc herniation ... See more keywords
Emerging Role for SRC family kinases in junction dynamics during spermatogenesis.
Sign Up to like & getrecommendations! Published in 2019 at "Reproduction"
DOI: 10.1530/rep-18-0440
Abstract: SRC family kinases (SFKs) are known regulators of multiple cellular events, including cell movement, differentiation, proliferation, survival, and apoptosis. SFKs are expressed virtually by all mammalian cells. They are non-receptor protein kinases that phosphorylate a… read more here.
Keywords: emerging role; src family; family kinases; junction ... See more keywords
Src Family Kinases in the Central Nervous System: Their Emerging Role in Pathophysiology of Migraine and Neuropathic Pain
Sign Up to like & getrecommendations! Published in 2020 at "Current Neuropharmacology"
DOI: 10.2174/1570159x18666200814180218
Abstract: Src family kinases (SFK) are a group of non-receptor tyrosine kinases which play a pivotal role in cellular responses and oncogenesis. Accumulating evidence suggest that SFK also act as a key component in signalling pathways… read more here.
Keywords: role; pain; family kinases; src family ... See more keywords
Src Family Kinases: A Potential Therapeutic Target for Acute Kidney Injury
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12070984
Abstract: Src family kinases (SFKs) are non-receptor tyrosine kinases and play a key role in regulating signal transduction. The mechanism of SFKs in various tumors has been widely studied, and there are more and more studies… read more here.
Keywords: acute kidney; kidney; kidney injury; family kinases ... See more keywords
Targeting SRC Family Kinases in Mesothelioma: Time to Upgrade
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12071866
Abstract: Malignant mesothelioma (MM) is a deadly tumor mainly caused by exposure to asbestos. Unfortunately, no current treatment is able to change significantly the natural history of the disease, which has a poor prognosis in the… read more here.
Keywords: kinases mesothelioma; mesothelioma time; targeting src; family ... See more keywords
In Mitosis You Are Not: The NIMA Family of Kinases in Aspergillus, Yeast, and Mammals
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23074041
Abstract: The Never in mitosis gene A (NIMA) family of serine/threonine kinases is a diverse group of protein kinases implicated in a wide variety of cellular processes, including cilia regulation, microtubule dynamics, mitotic processes, cell growth,… read more here.
Keywords: family; mitosis; kinases aspergillus; family kinases ... See more keywords
The NLRP3 Inflammasome Works as a Sensor for Detecting Hypoactivity of the Mitochondrial Src Family Kinases.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of immunology"
DOI: 10.4049/jimmunol.2200611
Abstract: Gefitinib (GF), the tyrosine kinase inhibitor (TKI) targeting epidermal growth factor receptor, initiates lung inflammation through the NLR family pyrin domain containing 3 (NLRP3) inflammasome. However, the molecular targets and mechanisms underlying the inflammatory action… read more here.
Keywords: hypoactivity; family; mitochondrial src; family kinases ... See more keywords