The relaxin family peptide receptor 1 (RXFP1): An emerging player in human health and disease
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.1194
Abstract: Relaxin/relaxin family peptide receptor 1 (RXFP1) signaling is important for both normal physiology and disease. Strong preclinical evidence supports relaxin as a potent antifibrotic molecule. However, relaxin‐based therapy failed in clinical trial in patients with… read more here.
Keywords: rxfp1; relaxin family; family peptide; peptide receptor ... See more keywords
Optimization of the first small-molecule relaxin/insulin-like family peptide receptor (RXFP1) agonists: Activation results in an antifibrotic gene expression profile.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.06.008
Abstract: A dose responsive quantitative high throughput screen (qHTS) of >350,000 compounds against a human relaxin/insulin-like family peptide receptor (RXFP1) transfected HEK293 cell line identified 2-acetamido-N-phenylbenzamides 1 and 3 with modest agonist activity. An extensive structure-activity study… read more here.
Keywords: like family; family peptide; insulin like; receptor rxfp1 ... See more keywords
Overexpression of relaxin family peptide receptor 3 in Escherichia coli and characterization of its ligand binding properties
Sign Up to like & getrecommendations! Published in 2018 at "Process Biochemistry"
DOI: 10.1016/j.procbio.2018.03.022
Abstract: Abstract Relaxin family peptide receptor 3 (RXFP3) is an A-class G protein-coupled receptor. It is implicated in the regulation of food intake and stress response upon activation by the neuropeptide relaxin-3. So far, preparation of… read more here.
Keywords: rxfp3; relaxin family; escherichia coli; family peptide ... See more keywords
Signal transduction pathways activated by insulin‐like peptide 5 at the relaxin family peptide RXFP4 receptor
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Pharmacology"
DOI: 10.1111/bph.13522
Abstract: Insulin‐like peptide 5 (INSL5) is a two‐chain, three‐disulfide‐bonded peptide of the insulin/relaxin superfamily, uniquely expressed in enteroendocrine L‐cells of the colon. It is the cognate ligand of relaxin family peptide RXFP4 receptor that is mainly… read more here.
Keywords: insulin; peptide; relaxin family; family peptide ... See more keywords
Expression and Characterization of Relaxin Family Peptide Receptor 1 Variants
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.826112
Abstract: G-protein coupled receptors (GPCR) transduce extracellular stimuli into the cell interior and are thus centrally involved in almost all physiological-neuronal processes. This essential function and association with many diseases or pathological conditions explain why GPCRs… read more here.
Keywords: relaxin family; peptide receptor; expression; family peptide ... See more keywords