hSSB1 phosphorylation is dynamically regulated by DNA-PK and PPP-family protein phosphatases.
Sign Up to like & getrecommendations! Published in 2017 at "DNA repair"
DOI: 10.1016/j.dnarep.2017.03.006
Abstract: The maintenance of genomic stability is essential for cellular viability and the prevention of diseases such as cancer. Human single-stranded DNA-binding protein 1 (hSSB1) is a protein with roles in the stabilisation and restart of… read more here.
Keywords: protein; protein phosphatases; dna; ppp family ... See more keywords
Characterization of DNA binding and ligand binding properties of the TetR family protein involved in regulation of dsz operon in Gordonia sp. IITR100.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.09.009
Abstract: Gordonia sp. IITR100 is a biodesulfurizing bacterium which can metabolize dibenzothiophene (DBT) to 2 hydroxybiphenyl in four steps via the 4S pathway. The genes involved in the metabolism are present in the form of an… read more here.
Keywords: protein; dna; family protein; ligand binding ... See more keywords
A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-15719-6
Abstract: Although cellular senescence acts primarily as a tumour suppression mechanism, the accumulation of senescent cells in vivo eventually exerts deleterious side effects through inflammatory/tumour-promoting factor secretion. Thus, the development of new drugs that cause the… read more here.
Keywords: senescent cells; family protein; provokes senolysis; protein degrader ... See more keywords
A new flavor of cellular Atg8-family protein lipidation – alternative conjugation to phosphatidylserine during CASM
Sign Up to like & getrecommendations! Published in 2021 at "Autophagy"
DOI: 10.1080/15548627.2021.1947730
Abstract: ABSTRACT Atg8-family protein lipidation is the most commonly used marker for monitoring autophagy. During macroautophagy, Atg8-family proteins are specifically conjugated to phosphatidylethanolamine (PE) in forming, double-membrane autophagosomes. A distinct, non-canonical autophagy pathway also operates, characterized… read more here.
Keywords: atg8 family; protein lipidation; family protein; family ... See more keywords
Hva22, a REEP family protein in fission yeast, promotes reticulophagy in collaboration with a receptor protein.
Sign Up to like & getrecommendations! Published in 2023 at "Autophagy"
DOI: 10.1080/15548627.2023.2214029
Abstract: The endoplasmic reticulum (ER) undergoes selective autophagy called reticulophagy or ER-phagy. Multiple reticulon- and receptor expression enhancing protein (REEP)-like ER-shaping proteins, including budding yeast Atg40, serve as reticulophagy receptors that stabilize the phagophore on the… read more here.
Keywords: reep family; yeast; family protein; fission yeast ... See more keywords
Microcephaly family protein MCPH1 stabilizes RAD51 filaments
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa636
Abstract: Abstract Microcephalin 1 (MCPH1) was identified from genetic mutations in patients with primary autosomal recessive microcephaly. In response to DNA double-strand breaks (DSBs), MCPH1 forms damage-induced foci and recruits BRCA2–RAD51 complex, a key component of… read more here.
Keywords: protein; microcephaly family; family protein; protein mcph1 ... See more keywords
PRpnp, a novel dual activity PNP family protein improves plant vigour and confers multiple stress tolerance in Citrus aurantifolia
Sign Up to like & getrecommendations! Published in 2023 at "Plant Biotechnology Journal"
DOI: 10.1111/pbi.13989
Abstract: Summary Under field conditions, plants are often simultaneously exposed to several abiotic and biotic stresses resulting in significant reductions in growth and yield; thus, developing a multi‐stress tolerant variety is imperative. Previously, we reported the… read more here.
Keywords: prpnp; pnp family; family protein; plant ... See more keywords
P200 family protein IFI204 negatively regulates type I interferon responses by targeting IRF7 in nucleus
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1008079
Abstract: Interferon-inducible p200 family protein IFI204 was reported to be involved in DNA sensing, and subsequently induces the production of type I interferons and proinflammatory mediators. However, its function in the regulation of antiviral innate immune… read more here.
Keywords: ifi204; family protein; type interferon; p200 family ... See more keywords
B7 family protein glycosylation: Promising novel targets in tumor treatment
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1088560
Abstract: Cancer immunotherapy, including the inhibition of immune checkpoints, improves the tumor immune microenvironment and is an effective tool for cancer therapy. More effective and alternative inhibitory targets are critical for successful immune checkpoint blockade therapy.… read more here.
Keywords: protein glycosylation; family; promising novel; glycosylation promising ... See more keywords
OVATE Family Protein PpOFP1 Physically Interacts With PpZFHD1 and Confers Salt Tolerance to Tomato and Yeast
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2021.759955
Abstract: The OVATE family protein (OFP) genes (OFPs) have been shown to respond to salt stress in plants. However, the regulatory mechanism for salt tolerance of the peach (Prunus persica) OFP gene PpOFP1 has not been… read more here.
Keywords: ovate family; salt tolerance; family protein; protein ... See more keywords
Genome-Wide Identification of Potential mRNAs in Drought Response in Wheat (Triticum aestivum L.)
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13101906
Abstract: Plant cell metabolism inevitably forms an important drought-responsive mechanism, which halts crop productivity. Globally, more than 30% of the total harvested area was affected by dehydration. RNA-seq technology has enabled biologists to identify stress-responsive genes… read more here.
Keywords: response wheat; family protein; drought response; protein ... See more keywords