Bacterial pseudokinase catalyzes protein polyglutamylation to inhibit the SidE-family ubiquitin ligases
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DOI: 10.1126/science.aaw7446
Abstract: Divergent protein kinase SidJ is a protein produced by Legionella pneumophila that orchestrates this intracellular pathogen's establishment within the host cell. SidJ prevents lysosome fusion with the vacuole, within which the bacterium resides and replicates.… read more here.
Keywords: family ubiquitin; ubiquitin ligases; polyglutamylation; host ... See more keywords
PO-127 Role of the NEDD4 family of E3 ubiquitin ligases in colorectal cancer pathogenesis and their potential as biomarkers
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DOI: 10.1136/esmoopen-2018-eacr25.168
Abstract: Introduction Colorectal cancer (CRC) is a global health challenge. There is limited response to standard oncological treatment and few stratified treatment options based on prognostic and/or predictive factors. The four biologically distinct and gene expression-based… read more here.
Keywords: family ubiquitin; colorectal cancer; ubiquitin ligases; crc ... See more keywords
Ubiquitination-coupled liquid phase separation regulates the accumulation of the TRIM family of ubiquitin ligases into cytoplasmic bodies
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DOI: 10.1371/journal.pone.0272700
Abstract: Many members of the tripartite motif (TRIM) family of ubiquitin ligases localize in spherical, membrane-free structures collectively referred to as cytoplasmic bodies (CBs) in a concentration-dependent manner. These CBs may function as aggresome precursors or… read more here.
Keywords: cytoplasmic bodies; family ubiquitin; trim family; ubiquitin ligases ... See more keywords