Targeted mass spectrometry enables robust quantification of FANCD2 mono-ubiquitination in response to DNA damage.
Sign Up to like & getrecommendations! Published in 2018 at "DNA repair"
DOI: 10.1016/j.dnarep.2018.03.003
Abstract: The Fanconi anemia pathway is an important coordinator of DNA repair pathways and is particularly relevant to repair of DNA inter-strand crosslinks. Central to the pathway is monoubiquitination of FANCD2, requiring the function of multiple… read more here.
Keywords: quantification; fancd2; mass spectrometry; dna ... See more keywords
Allosteric mechanism for site-specific ubiquitination of FANCD2
Sign Up to like & getrecommendations! Published in 2019 at "Nature chemical biology"
DOI: 10.1038/s41589-019-0426-z
Abstract: DNA-damage repair is implemented by proteins that are coordinated by specialized molecular signals. One such signal in the Fanconi anemia (FA) pathway for the repair of DNA interstrand crosslinks is the site-specific monoubiquitination of FANCD2… read more here.
Keywords: specific ubiquitination; mechanism; site specific; fancd2 ... See more keywords
FAN1's protection against CGG repeat expansion requires its nuclease activity and is FANCD2-independent.
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic acids research"
DOI: 10.1093/nar/gkab899
Abstract: The Repeat Expansion Diseases, a large group of human diseases that includes the fragile X-related disorders (FXDs) and Huntington's disease (HD), all result from expansion of a disease-specific microsatellite via a mechanism that is not… read more here.
Keywords: protection; expansion; nuclease activity; fancd2 ... See more keywords
Integrative analyses of prognosis, tumor immunity, and ceRNA network of the ferroptosis-associated gene FANCD2 in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.955225
Abstract: Extensive evidence has revealed that ferroptosis plays a vital role in HCC development and progression. Fanconi anemia complementation group D2 (FANCD2) has been reported to serve as a ferroptosis-associated gene and has a close relationship… read more here.
Keywords: associated gene; hcc; fancd2; ferroptosis associated ... See more keywords
Lymphopenia With Clinical and Laboratory Features of Combined Immune Deficiency in an 11-Year-Old Female With FANCD2 Variants and Fanconi Anemia
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Pediatrics"
DOI: 10.3389/fped.2018.00390
Abstract: Fanconi anemia (FA) is an inherited bone marrow failure and cancer predisposition disorder due to mutations in DNA repair pathways proteins (FANC). The dysfunctional proteins are unable to repair DNA breaks and cause genomic instability.… read more here.
Keywords: fanconi anemia; old female; fancd2; laboratory features ... See more keywords