A possible role of FANCM mutations in male breast cancer susceptibility: Results from a multicenter study in Italy.
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DOI: 10.1016/j.breast.2017.12.013
Abstract: INTRODUCTION Breast cancer (BC) in men is a rare disease, whose etiology appears to be associated with genetic factors. Inherited mutations in BRCA1/2 genes account for about 10-15% of all cases. FANCM, functionally linked to… read more here.
Keywords: fancm; fancm mutations; susceptibility; breast cancer ... See more keywords
A homozygous FANCM frameshift pathogenic variant causes male infertility
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DOI: 10.1038/s41436-018-0015-7
Abstract: PurposeFanconi anemia (FA) genes play important roles in spermatogenesis. In mice, disruption of Fancm impairs male fertility and testicular integrity, but whether FANCM pathogenic variants (PV) similarly affect fertility in men is unknown. Here we… read more here.
Keywords: homozygous fancm; fancm frameshift; male infertility; fancm ... See more keywords
Division of Labor by the HELQ, BLM, and FANCM Helicases during Homologous Recombination Repair in Drosophila melanogaster
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DOI: 10.3390/genes13030474
Abstract: Repair of DNA double-strand breaks by homologous recombination (HR) requires a carefully orchestrated sequence of events involving many proteins. One type of HR, synthesis-dependent strand annealing (SDSA), proceeds via the formation of a displacement loop… read more here.
Keywords: fancm; blm; helq; homologous recombination ... See more keywords