Physiological FAP-activation in a postpartum woman observed in oncological FAPI-PET/CT
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-021-05203-8
Abstract: Fibroblast activation protein (FAP) is a type II transmembrane serine protease overexpressed by cancer-associated fibroblasts [1]. However, high expression can also be observed in nonmalignant processes associated with tissue remodeling such as wound healing and… read more here.
Keywords: fapi pet; breast; fap; expression ... See more keywords
A Trifunctional Theranostic Ligand Targeting Fibroblast Activation Protein-α (FAPα)
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Imaging and Biology"
DOI: 10.1007/s11307-021-01593-1
Abstract: Fibroblast activation protein-α (FAPα) is uniquely expressed in activated fibroblasts, including cancer-associated fibroblasts that populate tumor stroma and contribute to proliferation and immunosuppression. Radiolabeled FAPα inhibitors enable imaging of multiple human cancers, but time-dependent clearance… read more here.
Keywords: fap; rps 309; activation protein; ligand ... See more keywords
S39 Familial amyloid polyneuropathy (FAP): All aspects of the disease from diagnosis to treatment: Disease description: What is FAP?
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Neurophysiology"
DOI: 10.1016/j.clinph.2017.07.050
Abstract: Transthyretin familial amyloid polyneuropathy (TTR-FAP) is a rare autosomal dominant disorder induced by the deposition of the mutated TTR protein as amyloid fibrils. It is a multisystemic disorder affecting several organs including but not limited… read more here.
Keywords: amyloid; diagnosis; amyloid polyneuropathy; familial amyloid ... See more keywords
Comparison of nonampullary duodenal adenomas in patients with familial adenomatous polyposis versus patients with sporadic adenomas.
Sign Up to like & getrecommendations! Published in 2017 at "Gastrointestinal endoscopy"
DOI: 10.1016/j.gie.2016.08.005
Abstract: BACKGROUND AND AIMS Nonampullary duodenal adenomas are either sporadic or associated with a hereditary syndrome such as familial adenomatous polyposis (FAP). The aim of this study is to compare characteristics and outcomes of sporadic and… read more here.
Keywords: duodenal adenomas; sporadic adenomas; pathology; fap ... See more keywords
Ultrasensitive Fibroblast Activation Protein-α-Activated Fluorogenic Probe Enables Selective Imaging and Killing of Melanoma In Vivo.
Sign Up to like & getrecommendations! Published in 2022 at "ACS sensors"
DOI: 10.1021/acssensors.2c00126
Abstract: Melanoma is a malignant cancer with a high risk of metastasis and continued increase in death rates over the past decades, and its prognosis is highly related to the disease's stage, while early detection and… read more here.
Keywords: activation protein; melanoma; fap; fluorogenic probe ... See more keywords
Heterozygous APC germline mutations impart predisposition to colorectal cancer
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-84564-4
Abstract: Familial adenomatous polyposis (FAP) is an inherited syndrome caused by a heterozygous adenomatous polyposis coli (APC) germline mutation, associated with a profound lifetime risk for colorectal cancer. While it is well accepted that tumorigenic transformation… read more here.
Keywords: germline mutations; fap; colon; heterozygous apc ... See more keywords
P11.41 Comparison of fibroblast activation protein expression and localization in glioblastomas and brain metastases
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz126.187
Abstract: Fibroblast activation protein (FAP) is a transmembrane serine protease that is frequently upregulated in the tumor microenvironment. In several cases, FAP protein itself and/or FAP expressing stromal cells have been shown to contribute to cancer… read more here.
Keywords: brain metastases; fap; glioblastomas brain; cancer ... See more keywords
Exploring the corrosion inhibition capability of FAP-based ionic liquids on stainless steel
Sign Up to like & getrecommendations! Published in 2020 at "Royal Society Open Science"
DOI: 10.1098/rsos.200580
Abstract: Corrosion is clearly one of the more common causes of materials failure in stainless steel. To manage corrosion, chemical inhibitors are often used for prevention and control. Ionic liquids due to their hydrophobic and corrosion-resistant… read more here.
Keywords: fap; stainless steel; corrosion; steel ... See more keywords
Functional Amyloids in Pseudomonas aeruginosa Are Essential for the Proteome Modulation That Leads to Pathoadaptation in Pulmonary Niches
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.03071-22
Abstract: Pseudomonas aeruginosa is inextricably linked with chronic lung infections. In this study, the well-conserved Fap operon was found to be essential for pathoadaptation in pulmonary infection in a rat lung model. ABSTRACT Persistence and survival… read more here.
Keywords: pathoadaptation pulmonary; pseudomonas aeruginosa; fap; infection ... See more keywords
286 Tumor targeting and tissue biodistribution of RO7122290, a novel FAP-targeted 4–1BB (CD137) agonist, in patients with advanced solid tumors, using [89Zr]-RO7122290 as a PET tracer
Sign Up to like & getrecommendations! Published in 2020 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2020-sitc2020.0286
Abstract: Background RO7122290 (RO) is a potent next generation 4-1BB agonist simultaneously targeting fibroblast activation protein (FAP). FAP is highly expressed on cancer-associated fibroblasts in many solid tumors, while expression in healthy tissue is low. 4… read more here.
Keywords: biodistribution; solid tumors; fap; tissue ... See more keywords
Fibroblast activation protein modulates left ventricular growth and matrix remodeling
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733029
Abstract: Background: Fibroblast Activation Protein (FAP) is abundantly expressed in cancer associated fibroblasts and contributes to activation of proteolytic cascades which alter extracellular matrix (ECM) remodeling. However, whether and to what degree FAP influences left ventricular… read more here.
Keywords: activation protein; fap; fibroblast activation; physiology ... See more keywords