Physiological FAP-activation in a postpartum woman observed in oncological FAPI-PET/CT
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-021-05203-8
Abstract: Fibroblast activation protein (FAP) is a type II transmembrane serine protease overexpressed by cancer-associated fibroblasts [1]. However, high expression can also be observed in nonmalignant processes associated with tissue remodeling such as wound healing and… read more here.
Keywords: fapi pet; breast; fap; expression ... See more keywords
A Trifunctional Theranostic Ligand Targeting Fibroblast Activation Protein-α (FAPα)
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Imaging and Biology"
DOI: 10.1007/s11307-021-01593-1
Abstract: Fibroblast activation protein-α (FAPα) is uniquely expressed in activated fibroblasts, including cancer-associated fibroblasts that populate tumor stroma and contribute to proliferation and immunosuppression. Radiolabeled FAPα inhibitors enable imaging of multiple human cancers, but time-dependent clearance… read more here.
Keywords: fap; rps 309; activation protein; ligand ... See more keywords
S39 Familial amyloid polyneuropathy (FAP): All aspects of the disease from diagnosis to treatment: Disease description: What is FAP?
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Neurophysiology"
DOI: 10.1016/j.clinph.2017.07.050
Abstract: Transthyretin familial amyloid polyneuropathy (TTR-FAP) is a rare autosomal dominant disorder induced by the deposition of the mutated TTR protein as amyloid fibrils. It is a multisystemic disorder affecting several organs including but not limited… read more here.
Keywords: amyloid; diagnosis; amyloid polyneuropathy; familial amyloid ... See more keywords
Comparison of nonampullary duodenal adenomas in patients with familial adenomatous polyposis versus patients with sporadic adenomas.
Sign Up to like & getrecommendations! Published in 2017 at "Gastrointestinal endoscopy"
DOI: 10.1016/j.gie.2016.08.005
Abstract: BACKGROUND AND AIMS Nonampullary duodenal adenomas are either sporadic or associated with a hereditary syndrome such as familial adenomatous polyposis (FAP). The aim of this study is to compare characteristics and outcomes of sporadic and… read more here.
Keywords: duodenal adenomas; sporadic adenomas; pathology; fap ... See more keywords
Development of an FAP-Targeted PET Probe Based on a Novel Quinolinium Molecular Scaffold.
Sign Up to like & getrecommendations! Published in 2024 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.4c00214
Abstract: Fibroblast activation protein (FAP) has recently gained significant attention as a promising tumor biomarker for both diagnosis and therapeutic applications. A series of radiopharmaceuticals based on fibroblast activation protein inhibitors (FAPIs) have been developed and… read more here.
Keywords: development fap; smic 3002; quinolinium; pet probe ... See more keywords
Development of Cysteic Acid-Modified FAP Radioligands for Enhanced Renal Clearance: From Preclinical Optimization to First-in-Human Study.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.5c01163
Abstract: Fibroblast activation protein (FAP)-targeting radioligands hold promise for cancer theranostics. Cyclic peptide-based DOTA-FAP-2286 radioligands have demonstrated high kidney uptake and retention, raising concerns regarding potential nephrotoxicity. Hence, we aimed to design three cysteic acid-modified FAP-targeting… read more here.
Keywords: acid modified; modified fap; fap 2286; cysteic acid ... See more keywords
Ultrasensitive Fibroblast Activation Protein-α-Activated Fluorogenic Probe Enables Selective Imaging and Killing of Melanoma In Vivo.
Sign Up to like & getrecommendations! Published in 2022 at "ACS sensors"
DOI: 10.1021/acssensors.2c00126
Abstract: Melanoma is a malignant cancer with a high risk of metastasis and continued increase in death rates over the past decades, and its prognosis is highly related to the disease's stage, while early detection and… read more here.
Keywords: activation protein; melanoma; fap; fluorogenic probe ... See more keywords
Heterozygous APC germline mutations impart predisposition to colorectal cancer
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-84564-4
Abstract: Familial adenomatous polyposis (FAP) is an inherited syndrome caused by a heterozygous adenomatous polyposis coli (APC) germline mutation, associated with a profound lifetime risk for colorectal cancer. While it is well accepted that tumorigenic transformation… read more here.
Keywords: germline mutations; fap; colon; heterozygous apc ... See more keywords
Tris(pentafluoroethyl)difluorophosphorane for fluoride abstraction and ligand exchange reactions of N-heterocyclic carbene and cyclic alkyl(amino)carbene copper(I) fluorides.
Sign Up to like & getrecommendations! Published in 2025 at "Dalton transactions"
DOI: 10.1039/d5dt00904a
Abstract: The synthesis and structural characterization of a variety of N-heterocyclic carbene (NHC)- and cyclic (alkyl)(amino)carbene (cAAC)-ligated cationic copper(I) complexes, featuring the weakly coordinating tris(pentafluoroethyl)trifluorophosphate counteranion (FAP- anion, [(C2F5)3PF3]-) are reported. Starting with the complex [(IDipp)Cu(C6Me6)]+FAP-… read more here.
Keywords: cyclic alkyl; heterocyclic carbene; ligand; carbene ... See more keywords
Symmetry-breaking malachite green as a near-infrared light-activated fluorogenic photosensitizer for RNA proximity labeling
Sign Up to like & getrecommendations! Published in 2024 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkae125
Abstract: Abstract Cellular RNA is asymmetrically distributed in cells and the regulation of RNA localization is crucial for proper cellular functions. However, limited chemical tools are available to capture dynamic RNA localization in complex biological systems… read more here.
Keywords: rna proximity; proximity labeling; light; fap ... See more keywords
NIMG-10. THE ROLE OF FIBROBLAST ACTIVATION PROTEIN IN GLIOBLASTOMA AND GLIOSARCOMA – A COMPARISON OF TISSUE, 68GA-FAPI-46 POSITRON EMISSION TOMOGRAPHY AND SURVIVAL DATA
Sign Up to like & getrecommendations! Published in 2024 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noae165.0776
Abstract: Despite their unique histological features,gliosarcomas belong to the group of glioblastomas and are treated according to the same standards. Fibroblast-activation-protein(FAP) is a component of a tumor-specific subpopulation of fibroblasts that play a critical role in… read more here.
Keywords: fap expression; gliosarcoma; tumor; expression ... See more keywords