Development of an FAP-Targeted PET Probe Based on a Novel Quinolinium Molecular Scaffold.
Sign Up to like & getrecommendations! Published in 2024 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.4c00214
Abstract: Fibroblast activation protein (FAP) has recently gained significant attention as a promising tumor biomarker for both diagnosis and therapeutic applications. A series of radiopharmaceuticals based on fibroblast activation protein inhibitors (FAPIs) have been developed and… read more here.
Keywords: development fap; smic 3002; quinolinium; pet probe ... See more keywords
FAP-Targeted Fluorescent Imaging Agents to Study Cancer-Associated Fibroblasts In Vivo
Sign Up to like & getrecommendations! Published in 2024 at "Bioconjugate Chemistry"
DOI: 10.1021/acs.bioconjchem.4c00426
Abstract: Cancer-associated fibroblasts (CAFs) expressing fibroblast activation protein alpha (FAP) are abundant in tumor microenvironments and represent an emerging target for PET cancer imaging. While different quinolone-based small molecule agents have been developed for whole-body imaging,… read more here.
Keywords: cancer; imaging agents; associated fibroblasts; cancer associated ... See more keywords
FAP-Targeted Radionuclide Therapy of Advanced Radioiodine-Refractory Differentiated Thyroid Cancer With Multiple Cycles of 177Lu-FAPI-46.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical nuclear medicine"
DOI: 10.1097/rlu.0000000000004260
Abstract: ABSTRACT Many recent studies began to explore the therapeutic potential of FAP-targeted radionuclide therapy for refractory cancers. In this case, we presented the experience of multiple cycles of 177Lu-FAPI-46 radionuclide therapy in a 34-year-old man… read more here.
Keywords: fap targeted; refractory; radionuclide therapy; 177lu fapi ... See more keywords
Recent Clinical Implications of FAPI
Sign Up to like & getrecommendations! Published in 2024 at "Clinical Nuclear Medicine"
DOI: 10.1097/rlu.0000000000005348
Abstract: Abstract The fibroblast activation protein (FAP) is a biomarker that is selectively overexpressed on cancer-associated fibroblasts (CAFs) in various types of tumoral tissues and some nonmalignant diseases, including fibrosis, arthritis, cardiovascular, and metabolic diseases. FAP… read more here.
Keywords: treatment; clinical implications; recent clinical; nonmalignant diseases ... See more keywords
FAP-targeted Radio-ligand Therapy in Pancreatic Neuroendocrine Tumor: A Potential Alternative to PRRT.
Sign Up to like & getrecommendations! Published in 2025 at "Clinical nuclear medicine"
DOI: 10.1097/rlu.0000000000006204
Abstract: A 47-year-old man presented with a grade II well-differentiated metastatic neuroendocrine tumor originating from the pancreas. Initial treatment included trans-arterial embolization, long-acting octreotide, followed by chemotherapy. Despite these interventions, progressive disease was noted, prompting evaluation… read more here.
Keywords: radio ligand; targeted radio; therapy; tumor ... See more keywords
Abstract 1988: FAP-targeted non-internalising drug conjugates: A comparative evaluation between small molecules, antibodies and peptides
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1988
Abstract: Conventional cancer chemotherapy relies on the use of cytotoxic drugs which are not designed and capable of selective accumulation to neoplastic lesions. The conjugation to tumour-targeting delivery vehicles has been proposed as a strategy to… read more here.
Keywords: fap targeted; comparative evaluation; drug conjugates; drug ... See more keywords
Abstract 2810: Increasing the efficacy of KRASG12Cinhibitor therapy through the adjuvant use of FAP targeted radiotherapy in a murine model of lung cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2810
Abstract: The purpose of this study was to evaluate the combined effects of KRAS targeted therapy and FAP targeted radiotherapy compared to either therapy alone in an animal model of lung cancer. KRAS is a protein… read more here.
Keywords: targeted radiotherapy; lung cancer; fap targeted; therapy ... See more keywords
Radioligands Targeting Fibroblast Activation Protein (FAP)
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13225744
Abstract: Simple Summary FAP-targeted radiotracers, recently introduced in cancer treatment, accumulate in Cancer-Associated Fibroblasts (CAFs). CAFs are present in tumor lesions but do not correspond to genuine cancer cells, although they behave in an abnormal and… read more here.
Keywords: medicine; nuclear medicine; fap targeted; fap ... See more keywords
Synthesis and Preclinical Evaluation of Two Novel 68Ga-Labeled Bispecific PSMA/FAP-Targeted Tracers with 2-Nal-Containing PSMA-Targeted Pharmacophore and Pyridine-Based FAP-Targeted Pharmacophore
Sign Up to like & getrecommendations! Published in 2024 at "Molecules"
DOI: 10.3390/molecules29040800
Abstract: Some bispecific radiotracers have been developed to overcome the limitations of monospecific tracers and improve detection sensitivity for heterogeneous tumor lesions. Here, we aim to synthesize two bispecific tracers targeting prostate-specific membrane antigen (PSMA) and… read more here.
Keywords: bispecific; psma targeted; psma; targeted pharmacophore ... See more keywords