IgG4-related disease revealed by 68Ga-FAPI and 18F-FDG PET/CT
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-019-04478-2
Abstract: A 58-year old man had been found with bilateral parotid mass and enlarged cervical lymph nodes for 5 months. Histopathology of the parotid mass showed abundant lymphoplasmacytic infiltration and collagen fibrosis, suggesting IgG4-related sialadenitis. Serum… read more here.
Keywords: igg4; pet; lymph nodes; fdg pet ... See more keywords
[68Ga]Ga-DOTA-FAPI-04 improves tumor staging and monitors early response to chemoradiotherapy in a patient with esophageal cancer
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-020-04818-7
Abstract: The main limitation of [F]FDG PET/CT in staging of esophageal cancer is its low-to-moderate sensitivity for lymph node staging [1, 2]. Previous studies demonstrated that [Ga]GaDOTA-FAPI-04 PET/CT allowed imaging of esophageal cancer with high tumor-to-background… read more here.
Keywords: esophageal cancer; tumor staging; dota fapi; fapi ... See more keywords
Reply: [68Ga]Ga-DOTA-FAPI-04 and [18F]FDG PET/CT for the diagnosis of primary and metastatic lesions in patients with hepatic cancer
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-020-04866-z
Abstract: Dear Sir, We would like to thank Dr. Yao and his colleagues for the important insights into the article “Comparison of [Ga]GaDOTA-FAPI-04 and [F]FDG PET/CT for the diagnosis of primary and metastatic lesions in patients… read more here.
Keywords: diagnosis; mass; fdg pet; dota fapi ... See more keywords
A theranostic approach of [68Ga]Ga-DOTA.SA.FAPi PET/CT-guided [177Lu]Lu-DOTA.SA.FAPi radionuclide therapy in an end-stage breast cancer patient: new frontier in targeted radionuclide therapy
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-020-04990-w
Abstract: A 31-year-young female was diagnosed with breast cancer in September 2019. The histopathology revealed atypical cells arranged cords and tubules in the fibrotic stroma suggestive of invasive ductal carcinoma of the breast and the immunohistochemistry… read more here.
Keywords: pet; dota fapi; fig; radionuclide therapy ... See more keywords
[68Ga]Ga-DOTA-FAPI-04 PET/CT imaging of benign pulmonary solitary fibrous tumour
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-021-05199-1
Abstract: A 27-year-old man with persistent cough and headache for 2months was referred to our hospital for further evaluation after a chest radiography revealed a large mass in the right lung. History revealed that he had… read more here.
Keywords: fapi pet; solitary fibrous; fibrous tumour; tumour ... See more keywords
68Ga-DOTA-FAPI-04 PET mimicking whole body bone scan in a patient with metabolic bone disease
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-021-05457-2
Abstract: A 63-year-old male had a history of kidney stones and recurrent hydronephrosis for more than 30 years. He received parathyroidectomy 1.5 years ago because of elevated serum calcium level (3.47 mmol/L, normal range 2.03–2.54 mmol/L)… read more here.
Keywords: fapi pet; 68ga dota; bone; fapi ... See more keywords
Development of Fibroblast Activation Protein Inhibitor-Based Dimeric Radiotracers with Improved Tumor Retention and Antitumor Efficacy.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00424
Abstract: Fibroblast activation protein (FAP), a fundamental component of the tumor stroma, is overexpressed in cancer-associated fibroblasts (CAFs). As a promising theranostic probe, we evaluated whether the FAP inhibitor (FAPI) dimer (DOTA-2P[FAPI]2) is more effective than… read more here.
Keywords: fapi; dota fapi; retention; 177lu dota ... See more keywords
86Y-Labeled Albumin-Binding Fibroblast Activation Protein Inhibitor for Late-Time-Point Cancer Diagnosis.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00579
Abstract: Fibroblast activation protein inhibitor (FAPI) is a novel quinoline-based radiopharmaceutical that has theranostic potential, yet the limited tumor retention hinders late-time diagnosis and radionuclide treatment. This study synthesized four albumin-binding FAPIs (TE-FAPI-01 to 04) and… read more here.
Keywords: activation protein; fapi; albumin binding; fibroblast activation ... See more keywords
Synthesis and Preclinical Evaluation of a Novel FAPI-04 Dimer for Cancer Theranostics.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00965
Abstract: Overexpression of fibroblast activation protein (FAP) in cancer-associated fibroblasts in a wide variety of tumors enables a highly selective targeting strategy using FAP inhibitors (FAPIs). Quinoline-based FAPIs labeled with radionuclides have been widely developed for… read more here.
Keywords: fapi; novel fapi; fapi dimer; 68ga fapi ... See more keywords
Visualization of Activated Fibroblasts in Heart Failure with Preserved Ejection Fraction with [18F]AlF-NOTA-FAPI-04 PET/CT Imaging
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.3c00075
Abstract: During the pathogenesis of heart failure with preserved ejection fraction (HFpEF), fibroblasts are activated and express the fibroblast activation protein (FAP). Targeted imaging of FAP can qualitatively and quantitatively assess the fibroblast activity. This study… read more here.
Keywords: fapi; nota fapi; pet; alf nota ... See more keywords
Advancement and Future Perspective of FAPI PET/CT In Gynecological Malignancies.
Sign Up to like & getrecommendations! Published in 2022 at "Seminars in nuclear medicine"
DOI: 10.1053/j.semnuclmed.2022.04.002
Abstract: Fibroblast activation protein (FAP) is ubiquitously present in healthy tissue, and additionally upregulated by cancer associated fibroblasts (CAFs) leading to high levels of FAP. Thus, neoplastic tissue, which is containing CAFs, characterized by a high… read more here.
Keywords: fapi; perspective fapi; pet gynecological; future perspective ... See more keywords