Synthesis and Preclinical Evaluation of a Novel FAPI-04 Dimer for Cancer Theranostics.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00965
Abstract: Overexpression of fibroblast activation protein (FAP) in cancer-associated fibroblasts in a wide variety of tumors enables a highly selective targeting strategy using FAP inhibitors (FAPIs). Quinoline-based FAPIs labeled with radionuclides have been widely developed for… read more here.
Keywords: fapi; novel fapi; fapi dimer; 68ga fapi ... See more keywords
Evaluation of a Novel Gd-FAPI Dimer Molecular Probe Targeting Fibroblast Activation Protein for Imaging of Solid Tumors
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DOI: 10.1021/acs.molpharmaceut.4c01175
Abstract: Cancer-associated fibroblasts (CAFs) are essential components of the tumor microenvironment. Fibroblast activation protein (FAP) is overexpressed in CAFs. FAP-targeted molecular imaging agents, including the FAP inhibitors (FAPIs), have shown promising results in tumor diagnosis. We… read more here.
Keywords: solid tumors; fibroblast activation; dimer; fapi dimer ... See more keywords