Novel β‐catenin/farnesoid X receptor interaction regulates hepatic bile acid metabolism during cholestasis
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.29584
Abstract: b -Catenin, a 781–amino acid, 85.5-kDa scaffold protein, serves a range of molecular functions including cell-to-cell adhesion to gene transcription. It is highly evolutionarily conserved and indispensable for embryonic development. bCatenin is a binding partner… read more here.
Keywords: catenin; catenin farnesoid; acid; adenomatous polyposis ... See more keywords
Reply to HEP-20-0140 Letter to the Editors: Could Butyrate Be Incorporated With Farnesoid X Receptor Agonist Cilofexor to Enhance Primary Sclerosing Cholangitis Treatment?
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology"
DOI: 10.1002/hep.31268
Abstract: We thank Drs. Chen and Vitetta for their letter regarding our manuscript describing our phase 2 study of the nonsteroidal farnesoid X receptor (FXR) agonist cilofexor in non-cirrhotic patients with primary sclerosing cholangitis (PSC).1 As… read more here.
Keywords: letter; primary sclerosing; sclerosing cholangitis; agonist cilofexor ... See more keywords
Farnesoid X Receptor Activation Impairs Liver Progenitor Cell–Mediated Liver Regeneration via the PTEN‐PI3K‐AKT‐mTOR Axis in Zebrafish
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology"
DOI: 10.1002/hep.31679
Abstract: Following mild liver injury, pre‐existing hepatocytes replicate. However, if hepatocyte proliferation is compromised, such as in chronic liver diseases, biliary epithelial cells (BECs) contribute to hepatocytes through liver progenitor cells (LPCs), thereby restoring hepatic mass… read more here.
Keywords: receptor activation; liver regeneration; regeneration; liver progenitor ... See more keywords
Mast Cells Regulate Ductular Reaction and Intestinal Inflammation in Cholestasis Through Farnesoid X Receptor Signaling
Sign Up to like & getrecommendations! Published in 2021 at "Hepatology"
DOI: 10.1002/hep.32028
Abstract: Cholestasis is characterized by increased total bile acid (TBA) levels, which are regulated by farnesoid X receptor (FXR)/FGF15. Patients with primary sclerosing cholangitis (PSC) typically present with inflammatory bowel disease (IBD). Mast cells (MCs) (i)… read more here.
Keywords: mast cells; cholestasis; ductular reaction; farnesoid receptor ... See more keywords
Discovery of Novel Molecular Frameworks of Farnesoid X Receptor Modulators by Ensemble Machine Learning
Sign Up to like & getrecommendations! Published in 2019 at "ChemistryOpen"
DOI: 10.1002/open.201800270
Abstract: Abstract Invited for this month's cover picture is the group of Prof. Dr. Gisbert Schneider from the Swiss Federal Institute of Technology (ETH) Zurich (Switzerland). The cover picture illustrates the application of machine‐learning methods to expand… read more here.
Keywords: machine; machine learning; farnesoid receptor; discovery novel ... See more keywords
Blinded evaluation of farnesoid X receptor (FXR) ligands binding using molecular docking and free energy calculations
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Computer-Aided Molecular Design"
DOI: 10.1007/s10822-017-0054-1
Abstract: Our participation to the D3R Grand Challenge 2 involved a protocol in two steps, with an initial analysis of the available structural data from the PDB allowing the selection of the most appropriate combination of… read more here.
Keywords: blinded evaluation; energy calculations; evaluation farnesoid; free energy ... See more keywords
GW29-e1697 Activation of Farnesoid X Receptor enhances the survival of engrafted adipose-derived mesenchymal stem cells in mouse post-MI heart
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2018.08.421
Abstract: The poor survival of engrafted stem cells in the ischemic environment limits their therapeutic efficacy for myocardial infarction (MI) treatment. Previously, we demonstrated that GW4064, an farnesoid X receptor (FXR) agonist, ameliorated post-MI cardiac dysfunction… read more here.
Keywords: survival engrafted; stem cells; farnesoid receptor;
Effects of active farnesoid X receptor on GLUTag enteroendocrine L cells
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2020.110923
Abstract: Activated transcription factor (TF) farnesoid X receptor (FXR) represses glucagon-like peptide-1 (GLP-1) secretion in enteroendocrine L cells. This, in turn, reduces insulin secretion, which is triggered when β cells bind GLP-1. Preventing FXR activation could… read more here.
Keywords: secretion; biology; enteroendocrine cells; farnesoid receptor ... See more keywords
Lignans from the seeds of Herpetospermum pedunculosum and their farnesoid X receptor-activating effect.
Sign Up to like & getrecommendations! Published in 2021 at "Phytochemistry"
DOI: 10.1016/j.phytochem.2021.113010
Abstract: The seeds of Herpetospermum pedunculosum (Ser.) C.B. Clarke, a well-known Tibetan medicine in China, are rich in kinds of bioactive lignans. In this phytochemical investigation on H. pedunculosum, sixteen undescribed lignans, named as herpedulins A… read more here.
Keywords: pedunculosum farnesoid; herpetospermum pedunculosum; seeds herpetospermum; lignans seeds ... See more keywords
Farnesoid X receptor (FXR) activation induces the antioxidant protein metallothionein 1 expression in mouse liver.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2020.111949
Abstract: Farnesoid X receptor (FXR) is a metabolic nuclear receptor, which protects liver from many endogenous and exogenous injuries. Metallothioneins (MTs) belong to a low-molecular-weight protein family involved in metal homeostasis and the regulation of hepatic… read more here.
Keywords: fxr; liver; expression; mouse ... See more keywords
Selective Photoaffinity Probe for Monitoring Farnesoid X Receptor Expression in Cultured Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c01206
Abstract: Farnesoid X receptor (FXR), a member of the nuclear receptor superfamily, is a vital ligand-activated transcriptional factor, which is highly expressed in the liver, intestine, and adrenal gland. However, FXR homeostasis is influenced by many… read more here.
Keywords: farnesoid receptor; selective photoaffinity; photoaffinity probe; expression ... See more keywords