Fas (CD95)/FasL (CD178) system during ageing.
Sign Up to like & getrecommendations! Published in 2023 at "Cell biology international"
DOI: 10.1002/cbin.12032
Abstract: The Fas/FasL system plays a central role in the physiological regulation of apoptosis and has been implicated in the pathogenesis of several neoplasms and diseases of the immune system. Until now, it has received little… read more here.
Keywords: system; fas cd95; fasl; fasl system ... See more keywords
Fas (CD95) expression in adipocytes contributes to diet‐induced obesity
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DOI: 10.1002/oby.24092
Abstract: Induction of browning in white adipose tissue (WAT) increases energy expenditure and may be an attractive target for the treatment of obesity. Since activation of Fas (CD95) induces pathways known to blunt expression of uncoupling… read more here.
Keywords: fas cd95; obesity; expression adipocytes; cd95 expression ... See more keywords
Polyubiquitination of p62/SQSTM1 is a prerequisite for Fas/CD95 aggregation to promote caspase-dependent apoptosis in cadmium-exposed mouse monocyte RAW264.7 cells
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-48684-2
Abstract: Cadmium(Cd) induces cytotoxicity via autophagy-induced apoptosis in non-activated mouse monocytes; however, the molecular mechanism remains unclear. Here, we show that autophagy induces Fas (CD95/APO-1)-mediated apoptosis by promoting accumulation of p62/SQSTM1 in response to Cd. Cd… read more here.
Keywords: fas; apoptosis; polyub; p62 sqstm1 ... See more keywords