Antitumor Activity of Fascaplysin Derivatives on Glioblastoma Model In Vitro
Sign Up to like & getrecommendations! Published in 2018 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-018-4055-4
Abstract: Antitumor efficiency of fascaplysin synthetic derivatives (7-phenylfascaplysin, 3-chlorofascaplysin, 3-bromofascaplysin, and 10-bromofascaplysin) was compared out in vitro on C6 glioma cells. The cytotoxic efficiency of all tested compounds was higher than that of unsubstituted fascaplysin; 3-bromofascaplysin… read more here.
Keywords: activity fascaplysin; glioma; fascaplysin derivatives; antitumor activity ... See more keywords
Syntheses of the marine alkaloids 6-oxofascaplysin, fascaplysin and their derivatives
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DOI: 10.1016/j.tetlet.2018.01.023
Abstract: Abstract A simple approach towards the pyrido[1,2-a:3,4-b′]diindole system via the reaction of indigo with methylene active compounds was used for the syntheses of the marine alkaloids 6-oxofascaplysin, fascaplysin, and their derivatives. It was also demonstrated… read more here.
Keywords: fascaplysin derivatives; oxofascaplysin fascaplysin; marine alkaloids; alkaloids oxofascaplysin ... See more keywords
Study of Structure–Activity Relationships of the Marine Alkaloid Fascaplysin and Its Derivatives as Potent Anticancer Agents
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DOI: 10.3390/md20030185
Abstract: Marine alkaloid fascaplysin and its derivatives are known to exhibit promising anticancer properties in vitro and in vivo. However, toxicity of these molecules to non-cancer cells was identified as a main limitation for their clinical… read more here.
Keywords: structure activity; alkaloid fascaplysin; fascaplysin derivatives; activity ... See more keywords