β1 Integrin is essential for fascin‐mediated breast cancer stem cell function and disease progression
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.32183
Abstract: Breast cancer remains the second cause of tumor‐related mortality in women worldwide mainly due to chemoresistance and metastasis. The chemoresistance and metastasis are attributed to a rare subpopulation with enriched stem‐like characteristics, thus called Cancer… read more here.
Keywords: chemoresistance; breast cancer; fascin; expression ... See more keywords
Studying the role of fascin-1 in mechanically stressed podocytes
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-10116-4
Abstract: Glomerular hypertension causes glomerulosclerosis via the loss of podocytes, which are challenged by increased mechanical load. We have demonstrated that podocytes are mechanosensitive. However, the response of podocytes to mechanical stretching remains incompletely understood. Here… read more here.
Keywords: mechanical stress; role fascin; fascin; role ... See more keywords
BP-1-102 and silencing of Fascin-1 by RNA interference inhibits the proliferation of mouse pituitary adenoma AtT20 cells via the signal transducer and activator of transcription 3/fascin-1 pathway
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Neuroscience"
DOI: 10.1080/00207454.2020.1758088
Abstract: Abstract Introduction The expression levels of signal transducer and activator of transcription 3 (STAT3) protein and Fascin-1 were inhibited using the STAT3 inhibitor BP-1-102 and RNA interference, respectively, to investigate the expression of AtT20 in… read more here.
Keywords: signal transducer; transducer activator; group; proliferation ... See more keywords
The actin-bundling protein Fascin-1 modulates ciliary signalling.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of molecular cell biology"
DOI: 10.1093/jmcb/mjad022
Abstract: Primary cilia are microtubule-based cell organelles important for cellular communication. Since they are involved in the regulation of numerous signalling pathways, defects in cilia development or function are associated with genetic disorders, collectively called ciliopathies.… read more here.
Keywords: protein fascin; ciliary signalling; protein; fascin ... See more keywords
Nuclear fascin regulates cancer cell survival
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.06.17.496538
Abstract: Fascin is an important regulator of F-actin bundling leading to enhanced filopodia assembly. Fascin is also overexpressed in most solid tumours where it supports invasion through control of F-actin structures at the periphery and nuclear… read more here.
Keywords: fascin regulates; nuclear fascin; fascin; cancer cell ... See more keywords
Sulfiredoxin Promotes Cancer Cell Invasion through Regulation of the miR143-Fascin Axis
Sign Up to like & getrecommendations! Published in 2022 at "Molecular and Cellular Biology"
DOI: 10.1128/mcb.00051-22
Abstract: Intracellular antioxidant enzymes are critical for maintenance of redox homeostasis, but whether and how they contribute to the malignancy of cancer cells remains poorly understood. ABSTRACT Intracellular antioxidant enzymes are critical for maintenance of redox… read more here.
Keywords: fascin axis; mir143 fascin; fascin; srx ... See more keywords
Abstract 3612: KAT8/SIRT7-medicated fascin-K41 acetylation/deacetylation regulates tumor metastasis
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3612
Abstract: Background: Although it is not expressed in the normal differentiated epithelial tissue of adult animals, fascin is highly expressed in a variety of cancers, including esophageal cancer, working as an important oncogenic protein. fascin promotes… read more here.
Keywords: acetylation; cancer; fascin k41; esophageal cancer ... See more keywords
Cooperative bundling by fascin generates actin structures with architectures that depend on filament length
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.974047
Abstract: The assembly of actin-based structures with precisely defined architectures supports essential cellular functions, including motility, intracellular transport, and division. The geometric arrangements of the filaments within actin structures are stabilized via the association of crosslinking… read more here.
Keywords: filament elongation; elongation; fascin; actin structures ... See more keywords
Anti-Metastasis Fascin Inhibitors Decrease the Growth of Specific Subtypes of Cancers
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12082287
Abstract: Fascin is an actin-bundling protein that is critical for filopodial formation and other cellular cytoskeletal structures. An elevated expression of fascin has been observed in tumor cells and is correlated with a shorter survival of… read more here.
Keywords: metastasis; fascin; growth specific; inhibitors decrease ... See more keywords
Structural Analysis of Human Fascin-1: Essential Protein for Actin Filaments Bundling
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12060843
Abstract: Fascin, a major actin cross-linking protein, is expressed in most vertebrate epithelial tissues. It organizes actin filaments into well-ordered bundles that are responsible for the extension of dynamic membrane protrusions, including microspikes, filopodia, and invadopodia… read more here.
Keywords: actin filaments; terminal region; actin; structural analysis ... See more keywords
In Silico Targeting of Fascin Protein for Cancer Therapy: Benchmarking, Virtual Screening and Molecular Dynamics Approaches
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28031296
Abstract: Fascin is an actin-bundling protein overexpressed in various invasive metastatic carcinomas through promoting cell migration and invasion. Therefore, blocking Fascin binding sites is considered a vital target for antimetastatic drugs. This inspired us to find… read more here.
Keywords: virtual screening; molecular dynamics; fascin; cancer ... See more keywords