Extracellular vesicles from the trematodes Fasciola hepatica and Dicrocoelium dendriticum trigger different responses in human THP‐1 macrophages
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12317
Abstract: Abstract Extracellular vesicles (EVs) released by the helminths Dicrocoelium dendriticum and Fasciola hepatica are important modulators of the host immune response, contributing to the establishment of the infection. Monocytes and, in particular, macrophages are major… read more here.
Keywords: fasciola hepatica; extracellular vesicles; dicrocoelium dendriticum; dendriticum ... See more keywords
Possible Role for Toll-Like Receptors in Interaction of Fasciola hepatica Excretory-Secretory Products with Human Monocyte Cell Line.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0475-5_12
Abstract: This chapter presents a proteomic approach to purify and identify native excretory-secretory products (ESPs) in the range of >10-30 kDa proteins capable of interacting with toll-like receptors (TLRs). Here we present a protocol to fractionate the… read more here.
Keywords: toll like; excretory secretory; secretory products; fasciola hepatica ... See more keywords
Testing Albendazole Resistance in Fasciola hepatica.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0475-5_16
Abstract: The egg development test is a useful in vitro tool to detect albendazole (ABZ) resistance in Fasciola hepatica. ABZ is the only flukicidal compound with ovicidal activity. The described test is based on the ABZ… read more here.
Keywords: resistance fasciola; fasciola hepatica; hepatica; resistance ... See more keywords
Isolation of Secreted and Tegumental Surface Proteins from Fasciola hepatica.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0475-5_3
Abstract: Proteins secreted by, or displayed on the surface tegument of, trematodes have key functions in the host-parasite interaction. As such, they are often leading targets for diagnostic tests or vaccine candidates. Here we describe methods… read more here.
Keywords: tegumental surface; fasciola hepatica; surface; secreted tegumental ... See more keywords
Genetic diversity of Fasciola hepatica in Austria
Sign Up to like & getrecommendations! Published in 2020 at "Parasitology Research"
DOI: 10.1007/s00436-020-06633-3
Abstract: The worldwide occurring common liver fluke Fasciola hepatica can infect humans and animals and leads to considerable illness and economic loss annually. The aim of this study was to determine the genetic diversity of F.… read more here.
Keywords: diversity; genetic diversity; fasciola hepatica; hepatica ... See more keywords
A host-independent role for Fasciola hepatica transforming growth factor-like molecule in parasite development.
Sign Up to like & getrecommendations! Published in 2021 at "International journal for parasitology"
DOI: 10.1016/j.ijpara.2020.11.005
Abstract: The trematode parasite Fasciola hepatica causes chronic infection in hosts, enabled by an immunosuppressed environment. Both host and parasite factors are known to contribute to this suggesting that avoidance of immunopathology is beneficial to both… read more here.
Keywords: transforming growth; fasciola hepatica; host; growth ... See more keywords
Dectin-1 on macrophages modulates the immune response to Fasciola hepatica products through the ERK signaling pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Immunobiology"
DOI: 10.1016/j.imbio.2018.08.004
Abstract: Fasciolosis is a zoonotic disease of increasing importance due to its worldwide distribution and elevated economic losses. Previously, we demonstrated that Fasciola hepatica excretory-secretory products (FhESP) induce immunomodulatory effects on peritoneal macrophages in a Dectin-1… read more here.
Keywords: fasciola hepatica; peritoneal macrophages; hepatica products; hepatica ... See more keywords
Fibrinogen and fibrin are novel substrates for Fasciola hepatica cathepsin L peptidases.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and biochemical parasitology"
DOI: 10.1016/j.molbiopara.2018.02.001
Abstract: Cathepsin peptidases form a major component of the secreted proteins of the blood-feeding trematodes Fasciola hepatica and Schistosoma mansoni. These peptidases fulfill many functions, from facilitating infection to feeding and immune evasion. In this study,… read more here.
Keywords: novel substrates; fibrinogen fibrin; fasciola hepatica; cathepsin ... See more keywords
Revealing genetic hybridization and DNA recombination of Fasciola hepatica and Fasciola gigantica in nuclear introns of the hybrid Fasciola flukes.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and biochemical parasitology"
DOI: 10.1016/j.molbiopara.2018.06.004
Abstract: Fasciola hepatica and F. gigantica are ruminant liver flukes that are found worldwide. They can occur sympatrically and hybridize, consequently producing an intermediate form (Fasciola sp.), especially in Africa and Asia. The bridge intron (TkBridgeInt)… read more here.
Keywords: fasciola; genetic hybridization; fasciola hepatica; hepatica ... See more keywords
Genererating a core cluster of Fasciola hepatica virulence and immunomodulation-related genes using a comparative in silico approach.
Sign Up to like & getrecommendations! Published in 2018 at "Research in veterinary science"
DOI: 10.1016/j.rvsc.2017.12.023
Abstract: A total of 71 virulence and immunomodulation-related transcripts (VIRs) of Fasciola hepatica have been previously proposed (Haçarız et al., 2015). In an attempt to further refine this cohort, an in silico meta analysis approach was… read more here.
Keywords: fasciola hepatica; virulence immunomodulation; silico; immunomodulation related ... See more keywords
Vaccination against Fasciola hepatica using cathepsin L3 and B3 proteases delivered alone or in combination.
Sign Up to like & getrecommendations! Published in 2018 at "Veterinary parasitology"
DOI: 10.1016/j.vetpar.2017.12.007
Abstract: No licensed vaccine is currently available for prevention of Fasciola hepatica infections. However, considering the alarming increase in drug resistance, there is an urgent need for a safe and fully effective vaccine against fasciolosis. Here,… read more here.
Keywords: liver fluke; alone combination; fasciola hepatica; vaccine ... See more keywords