Fas (CD95)/FasL (CD178) system during ageing.
Sign Up to like & getrecommendations! Published in 2023 at "Cell biology international"
DOI: 10.1002/cbin.12032
Abstract: The Fas/FasL system plays a central role in the physiological regulation of apoptosis and has been implicated in the pathogenesis of several neoplasms and diseases of the immune system. Until now, it has received little… read more here.
Keywords: system; fas cd95; fasl; fasl system ... See more keywords
FasL-PDPK1 Pathway Promotes the Cytotoxicity of CD8+ T Cells During Ischemic Stroke
Sign Up to like & getrecommendations! Published in 2020 at "Translational Stroke Research"
DOI: 10.1007/s12975-019-00749-0
Abstract: CD8+ T cells are recognized as key players in exacerbation of ischemic stroke; however, the underlying mechanism in modulating the function of CD8+ T cells has not been completely elucidated. Here, we uncovered that FasL… read more here.
Keywords: ischemic stroke; cd8; cd8 cells; cytotoxicity cd8 ... See more keywords
Molecular mechanisms of FasL-mediated 'reverse-signaling'.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular immunology"
DOI: 10.1016/j.molimm.2020.08.010
Abstract: Effector lymphocytes, including NK and T cells, express FasL. Expression of Fas, the receptor for FasL in tumor cells, renders them susceptible to NK and T cell-mediated killing. The functional relevance of FasL in initiating… read more here.
Keywords: mediated reverse; signaling molecular; fasl mediated; molecular mechanisms ... See more keywords
Fentanyl alleviates intestinal mucosal barrier damage in rats with severe acute pancreatitis by inhibiting the MMP-9/FasL/Fas pathway
Sign Up to like & getrecommendations! Published in 2022 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2022.2082304
Abstract: Abstract Background Fentanyl is an analgesic used against pancreatitis-related pain, while whether it ameliorates severe acute pancreatitis (SAP) has yet to be checked. This study aims to determine fentanyl-delivered effect on SAP and the mechanism… read more here.
Keywords: severe acute; fasl; fentanyl; acute pancreatitis ... See more keywords
Ambivalent role of FasL in murine acute graft-versus-host-disease.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of leukocyte biology"
DOI: 10.1093/jleuko/qiad040
Abstract: Fas ligand (FasL) is increased in several immune-mediated diseases, including acute graft versus host disease (aGVHD), a donor cell-mediated disorder post-hematopoietic stem cell transplantation (post-HSCT). In this disease, FasL is involved in T-cell mediated damage… read more here.
Keywords: disease; fasl; acute graft; graft ... See more keywords
A Fas Ligand (FasL)-Fused Humanized Antibody Against Tumor-Associated Glycoprotein 72 Selectively Exhibits the Cytotoxic Effect Against Oral Cancer Cells with a Low FasL/Fas Ratio
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-16-0314
Abstract: Altered expression of the Fas ligand (FasL)/Fas ratio exhibits a direct impact on the prognosis of cancer patients, and its impairment in cancer cells may lead to apoptosis resistance. Thus, the development of effective therapies… read more here.
Keywords: tumor; fas; fas ratio; fasl fas ... See more keywords
sFasL—The Key to a Riddle: Immune Responses in Aging Lung and Disease
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22042177
Abstract: By dint of the aging population and further deepened with the Covid-19 pandemic, lung disease has turned out to be a major cause of worldwide morbidity and mortality. The condition is exacerbated when the immune… read more here.
Keywords: sfasl; lung disease; lung; cell ... See more keywords
Differential expression patterns of the short and long isoform of cFLIP on FasL‑mediated apoptosis.
Sign Up to like & getrecommendations! Published in 2018 at "Oncology reports"
DOI: 10.3892/or.2018.6317
Abstract: cFLIP is a key regulator of the anti‑apoptotic mechanism and its association with FAS‑mediated apoptosis has been widely studied and well documented. However, the equipoise between its two isoforms i.e. the long isoform cFLIP(L) and… read more here.
Keywords: apoptosis; isoform cflip; cflip; expression ... See more keywords