Fatty Acid Synthase Promotes the Palmitoylation of Chikungunya Virus nsP1
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DOI: 10.1128/jvi.01747-18
Abstract: S-palmitoylation is an important form of lipid posttranslational modification, which affects the function of proteins by regulating their transport, stability, and localization. Previous studies have shown that FASN is critical for CHIKV replication; however, the… read more here.
Keywords: chikv replication; palmitoylation; fasn; nsp1 palmitoylation ... See more keywords
Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans
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DOI: 10.1136/gutjnl-2018-317581
Abstract: Objective Increased de novo fatty acid (FA) synthesis and cholesterol biosynthesis have been independently described in many tumour types, including hepatocellular carcinoma (HCC). Design We investigated the functional contribution of fatty acid synthase (Fasn)-mediated de… read more here.
Keywords: hcc; cholesterol; cholesterol biosynthesis; mice ... See more keywords
460 The immuno-metabolic enzyme FASN prevents anti-tumor immune responses in irradiated glioblastoma
Sign Up to like & getrecommendations! Published in 2020 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2020-sitc2020.0460
Abstract: Background Immunotherapy (IT) has evolved as an essential pillar against cancer due to unprecedented successes in several malignancies. However, only 10% of glioblastoma (GBM) patients respond to IT, presumably due to the paucity of tumor-infiltrating… read more here.
Keywords: gl261 cells; gbm; anti tumor; tumor immune ... See more keywords
Abstract 2219: Cancer prevention using a novel fatty acid synthase inhibitor
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DOI: 10.1158/1538-7445.am2017-2219
Abstract: Tumor growth and survival is dependent upon de novo fatty acid synthesis regulated via preferential upregulation of fatty acid synthase (FASN) in tumor cells. Here a novel FASN inhibitor that has shown antitumor activity in… read more here.
Keywords: inhibitor; fatty acid; cancer; fasn ... See more keywords
Abstract 2581: Fatty acid synthase regulates expression of Notum in colorectal cancer
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DOI: 10.1158/1538-7445.am2023-2581
Abstract: Background: Upregulation of lipid synthesis has been associated with poor clinical outcomes in colorectal cancer (CRC). Fatty acid synthase (FASN) synthesizes 16-carbon fatty acid palmitate which can be utilized for post-translational modifications of various proteins.… read more here.
Keywords: expression notum; expression; viability; fasn ... See more keywords
Abstract PS19-22: Fatty acid synthase enzyme as a mediator of obesity-induced breast cancer
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs20-ps19-22
Abstract: INTRODUCTION: Breast cancer accounts for nearly 40,000 deaths annually with the overall prognosis worsened if the patient is obese. Reprogramming of lipid metabolism in cancer is an established hallmark and contributes to tumorigenesis and drug-resistance.… read more here.
Keywords: expression; fasn; obesity induced; cancer ... See more keywords
The role of CA-125, GLS and FASN in predicting cytoreduction for epithelial ovarian cancers
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DOI: 10.1186/s13104-020-05188-x
Abstract: Cytoreduction has an important role in improving the survival rate of epithelial ovarian cancer (EOC) patients. This study aimed to assess the ability of preoperative serum CA125, FASN and GLS as predictors of cytoreductive surgery… read more here.
Keywords: gls; epithelial ovarian; 125 gls; cytoreduction ... See more keywords
Diallyl Sulfide-Mediated Modulation of the Fatty Acid Synthase (FASN) Leads to Cancer Cell Death in BaP-Induced Lung Carcinogenesis in Swiss Mice
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s284279
Abstract: Purpose Diallyl sulfide (DAS), one of the organo-sulfur secondary metabolites in garlic, has been shown to inhibit the proliferation of cancer cells. The present study aimed to evaluate the mechanism of DAS in the prevention… read more here.
Keywords: mice; fasn; induced lung; cancer ... See more keywords
Liver X receptor α promotes milk fat synthesis in buffalo mammary epithelial cells by regulating the expression of FASN.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of dairy science"
DOI: 10.3168/jds.2021-20596
Abstract: Liver X receptor α (LXRα; NR1H3) is an important transcription factor that can facilitate milk fat synthesis by regulating the transcription of FASN in mice and goats. Nevertheless, the lipid synthesis related to LXRα and… read more here.
Keywords: milk fat; buffalo mammary; fat synthesis; fasn ... See more keywords
The Pharmacological or Genetic Blockade of Endogenous De Novo Fatty Acid Synthesis Does Not Increase the Uptake of Exogenous Lipids in Ovarian Cancer Cells
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.610885
Abstract: Ovarian cancer(OC) is a serious threat to women worldwide. Peritoneal dissemination, ascites and omental metastasis are typical features for disease progression, which occurs in a micro-environment that is rich in high-energy lipids. OC cells require… read more here.
Keywords: fatty acid; uptake exogenous; ovarian cancer; exogenous lipids ... See more keywords
Concomitant Inhibition of FASN and SREBP Provides a Promising Therapy for CTCL
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DOI: 10.3390/cancers14184491
Abstract: Simple Summary The biosynthesis of fatty acids catalysed by FASN plays an important oncogenic role in various malignancies but has not been reported in CTCL yet. Here, we show that FASN is highly expressed in… read more here.
Keywords: cell; ctcl; fasn srebp; inhibition fasn ... See more keywords