Liraglutide mitigates dexamethasone-induced fatty acid synthase (FASN) and the cluster of differentiation36 (CD36) expression: a potential treatment for glucocorticoid-induced non-alcoholic fatty liver disease (NAFLD)
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DOI: 10.1007/s00210-025-03789-6
Abstract: The clinical use of dexamethasone (DXM) is associated with the development of non-alcoholic fatty liver disease (NAFLD). However, the mechanisms by which DXM-induced NAFLD is still incompletely known. Therefore, the current study aims to test… read more here.
Keywords: fasn cd36; treatment; dxm; fasn ... See more keywords
Multiple strategies association revealed functional candidate FASN gene for fatty acid composition in cattle
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DOI: 10.1038/s42003-025-07604-z
Abstract: Fatty acid composition (FA) is an important indicator of meat quality in beef cattle. We investigated potential functional candidate genes for FA in beef cattle by integrating genomic and transcriptomic dataset through multiple strategies. In… read more here.
Keywords: multiple strategies; fasn; acid composition; candidate ... See more keywords
Fatty Acid Synthase Promotes the Palmitoylation of Chikungunya Virus nsP1
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DOI: 10.1128/jvi.01747-18
Abstract: S-palmitoylation is an important form of lipid posttranslational modification, which affects the function of proteins by regulating their transport, stability, and localization. Previous studies have shown that FASN is critical for CHIKV replication; however, the… read more here.
Keywords: chikv replication; palmitoylation; fasn; nsp1 palmitoylation ... See more keywords
Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans
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DOI: 10.1136/gutjnl-2018-317581
Abstract: Objective Increased de novo fatty acid (FA) synthesis and cholesterol biosynthesis have been independently described in many tumour types, including hepatocellular carcinoma (HCC). Design We investigated the functional contribution of fatty acid synthase (Fasn)-mediated de… read more here.
Keywords: hcc; cholesterol; cholesterol biosynthesis; mice ... See more keywords
460 The immuno-metabolic enzyme FASN prevents anti-tumor immune responses in irradiated glioblastoma
Sign Up to like & getrecommendations! Published in 2020 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2020-sitc2020.0460
Abstract: Background Immunotherapy (IT) has evolved as an essential pillar against cancer due to unprecedented successes in several malignancies. However, only 10% of glioblastoma (GBM) patients respond to IT, presumably due to the paucity of tumor-infiltrating… read more here.
Keywords: gl261 cells; gbm; anti tumor; tumor immune ... See more keywords
Abstract 2219: Cancer prevention using a novel fatty acid synthase inhibitor
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DOI: 10.1158/1538-7445.am2017-2219
Abstract: Tumor growth and survival is dependent upon de novo fatty acid synthesis regulated via preferential upregulation of fatty acid synthase (FASN) in tumor cells. Here a novel FASN inhibitor that has shown antitumor activity in… read more here.
Keywords: inhibitor; fatty acid; cancer; fasn ... See more keywords
Abstract 2581: Fatty acid synthase regulates expression of Notum in colorectal cancer
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DOI: 10.1158/1538-7445.am2023-2581
Abstract: Background: Upregulation of lipid synthesis has been associated with poor clinical outcomes in colorectal cancer (CRC). Fatty acid synthase (FASN) synthesizes 16-carbon fatty acid palmitate which can be utilized for post-translational modifications of various proteins.… read more here.
Keywords: expression notum; expression; viability; fasn ... See more keywords
Abstract 5523: Inhibition of FASN postpones development of resistance to PLX8394 in colorectal cancer
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DOI: 10.1158/1538-7445.am2025-5523
Abstract: Mutations in proto-oncogene B-Raf (BRAF) occur in about 10% of colorectal cancer (CRC) patients and BRAFV600E is the most common type. This subset of CRC is associated with a reduced response to chemotherapy and poor… read more here.
Keywords: resistance; fasn; crc; resistance plx8394 ... See more keywords
Abstract PS19-22: Fatty acid synthase enzyme as a mediator of obesity-induced breast cancer
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DOI: 10.1158/1538-7445.sabcs20-ps19-22
Abstract: INTRODUCTION: Breast cancer accounts for nearly 40,000 deaths annually with the overall prognosis worsened if the patient is obese. Reprogramming of lipid metabolism in cancer is an established hallmark and contributes to tumorigenesis and drug-resistance.… read more here.
Keywords: expression; fasn; obesity induced; cancer ... See more keywords
Fatty Acid Synthase (FASN) Maintains Leukemogenesis By Suppressing Progranulin-Engaged Lysosomal and Inflammatory Signaling
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DOI: 10.1182/blood-2024-200731
Abstract: Cancer cells rely on lipogenesis in addition to the exogenous lipid up-taking, in which the lipogenic enzyme fatty acid synthase has aberrant over-expression in various cancers, including myeloid leukemia. However, the precise role of FASN… read more here.
Keywords: lysosomal inflammatory; acid synthase; fasn; cell ... See more keywords
SPICE1 promotes osteosarcoma growth by enhancing the deubiquitination of FASN mediated by USP10
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DOI: 10.1186/s12967-025-06248-1
Abstract: Osteosarcoma (OS) is recognized as a prevalent primary bone malignancy, particularly affecting adolescents during their growth spurts. Despite its clinical significance, the underlying biological characteristics and associated prognostic factors remain incompletely understood. The identification of… read more here.
Keywords: spice1 promotes; deubiquitination; usp10 fasn; fasn ... See more keywords