Using fast-acting temperature-sensitive mutants to study cell division in Caenorhabditis elegans.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in cell biology"
DOI: 10.1016/bs.mcb.2016.05.004
Abstract: Fast-acting temperature-sensitive (ts) mutations are powerful conditional tools for studying transient cellular processes such as cytokinesis. Fast-acting ts cytokinesis-defective mutants are functional at the permissive temperature; yet show a fully penetrant loss-of-function cytokinesis failure phenotype… read more here.
Keywords: temperature; acting temperature; cell division; temperature sensitive ... See more keywords
Property activity refinement of 2-anilino 4-amino substituted quinazolines as antimalarials with fast acting asexual parasite activity.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.105359
Abstract: Malaria is a devastating disease caused by Plasmodium parasites. Emerging resistance against current antimalarial therapeutics has engendered the need to develop antimalarials with novel structural classes. We recently described the identification and initial optimization of… read more here.
Keywords: class; asexual parasite; parasite activity; fast acting ... See more keywords
New Insight Into the Mechanisms of Fast-Acting Antidepressants: What We Learn From Scopolamine
Sign Up to like & getrecommendations! Published in 2018 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2017.11.001
Abstract: For a depressed patient, a single day without symptom improvement means yet another day of suffering. The currently available antidepressants require weeks or months to achieve appreciable symptom remission and remain ineffective in a large… read more here.
Keywords: acting antidepressants; new insight; fast acting; rapid antidepressant ... See more keywords
A novel class of fast‐acting antimalarial agents: Substituted 15‐membered azalides
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15292
Abstract: Efficacy of current antimalarial treatments is declining as a result of increasing antimalarial drug resistance, so new and potent antimalarial drugs are urgently needed. Azithromycin, an azalide antibiotic, was found useful in malaria therapy, but… read more here.
Keywords: antimalarial agents; acting antimalarial; class fast; fast acting ... See more keywords
Mealtime fast‐acting insulin aspart versus insulin aspart for controlling postprandial hyperglycaemia in people with insulin‐resistant Type 2 diabetes
Sign Up to like & getrecommendations! Published in 2019 at "Diabetic Medicine"
DOI: 10.1111/dme.13866
Abstract: This post hoc analysis explored whether mealtime fast‐acting insulin aspart treatment provided an advantage in postprandial plasma glucose (PPG) control vs. insulin aspart in people with Type 2 diabetes receiving high doses of bolus insulin. read more here.
Keywords: aspart; mealtime fast; insulin aspart; type diabetes ... See more keywords
Light-activated molecular machines are fast-acting broad-spectrum antibacterials that target the membrane
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abm2055
Abstract: The increasing occurrence of antibiotic-resistant bacteria and the dwindling antibiotic research and development pipeline have created a pressing global health crisis. Here, we report the discovery of a distinctive antibacterial therapy that uses visible (405… read more here.
Keywords: machines fast; activated molecular; mms; molecular machines ... See more keywords
Investigation of Pump Compatibility of Fast-Acting Insulin Aspart in Subjects With Type 1 Diabetes
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Diabetes Science and Technology"
DOI: 10.1177/1932296817730375
Abstract: Background: Ultra-fast-acting insulins, such as fast-acting insulin aspart (faster aspart), have pharmacokinetic properties that may be advantageous for patients using continuous subcutaneous insulin infusion (CSII), provided that they are compatible with and safe to use… read more here.
Keywords: infusion; faster aspart; insulin aspart; fast acting ... See more keywords
Effects of Slow- and Fast-Acting Compression on Hearing-Impaired Listeners’ Consonant–Vowel Identification in Interrupted Noise
Sign Up to like & getrecommendations! Published in 2018 at "Trends in Hearing"
DOI: 10.1177/2331216518800870
Abstract: There is conflicting evidence about the relative benefit of slow- and fast-acting compression for speech intelligibility. It has been hypothesized that fast-acting compression improves audibility at low signal-to-noise ratios (SNRs) but may distort the speech… read more here.
Keywords: compression; speech; slow fast; noise ... See more keywords
Efficacy and safety of fast-acting insulin aspart compared with insulin aspart in combination with insulin degludec in Japanese adults with type 1 diabetes: a subgroup analysis of the randomized onset 8 trial.
Sign Up to like & getrecommendations! Published in 2020 at "Endocrine journal"
DOI: 10.1507/endocrj.ej20-0606
Abstract: This study aimed to confirm the efficacy and safety of mealtime and post-meal fast-acting insulin aspart versus insulin aspart, both with basal insulin degludec, in Japanese patients with type 1 diabetes. This was a subgroup… read more here.
Keywords: insulin; insulin aspart; acting insulin; fast acting ... See more keywords
Characterization of Domiphen Bromide as a New Fast-Acting Antiplasmodial Agent Inhibiting the Apicoplastidic Methyl Erythritol Phosphate Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14071320
Abstract: The evolution of resistance by the malaria parasite to artemisinin, the key component of the combination therapy strategies that are at the core of current antimalarial treatments, calls for the urgent identification of new fast-acting… read more here.
Keywords: pathway; methyl erythritol; domiphen bromide; new fast ... See more keywords