Fast-acting antidepressant-like effects of ketamine in aged male rats
Sign Up to like & getrecommendations! Published in 2024 at "Pharmacological Reports"
DOI: 10.1007/s43440-024-00636-y
Abstract: The aging process causes anatomical and physiological changes that predispose to the development of late-life depression while reduces the efficacy of classical antidepressants. Novel fast-acting antidepressants such as ketamine might be good candidates to be… read more here.
Keywords: fast acting; effects ketamine; like effects; acting antidepressant ... See more keywords
Using fast-acting temperature-sensitive mutants to study cell division in Caenorhabditis elegans.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in cell biology"
DOI: 10.1016/bs.mcb.2016.05.004
Abstract: Fast-acting temperature-sensitive (ts) mutations are powerful conditional tools for studying transient cellular processes such as cytokinesis. Fast-acting ts cytokinesis-defective mutants are functional at the permissive temperature; yet show a fully penetrant loss-of-function cytokinesis failure phenotype… read more here.
Keywords: temperature; acting temperature; cell division; temperature sensitive ... See more keywords
Property activity refinement of 2-anilino 4-amino substituted quinazolines as antimalarials with fast acting asexual parasite activity.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.105359
Abstract: Malaria is a devastating disease caused by Plasmodium parasites. Emerging resistance against current antimalarial therapeutics has engendered the need to develop antimalarials with novel structural classes. We recently described the identification and initial optimization of… read more here.
Keywords: class; asexual parasite; parasite activity; fast acting ... See more keywords
New Insight Into the Mechanisms of Fast-Acting Antidepressants: What We Learn From Scopolamine
Sign Up to like & getrecommendations! Published in 2018 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2017.11.001
Abstract: For a depressed patient, a single day without symptom improvement means yet another day of suffering. The currently available antidepressants require weeks or months to achieve appreciable symptom remission and remain ineffective in a large… read more here.
Keywords: acting antidepressants; new insight; fast acting; rapid antidepressant ... See more keywords
Lemongrass (Cymbopogon citratus) essential oil: an eco-friendly and fast-acting acaricide against the grain pest mite Aleuroglyphus ovatus
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Acarology"
DOI: 10.1080/01647954.2024.2394213
Abstract: ABSTRACT This study was designed to evaluate the acaricidal effect and the mode of action of lemongrass essential oil (LEO) against Aleuroglyphus ovatus. Contact and fumigant mortality indicated that LEO had higher acaricidal activities at… read more here.
Keywords: fast acting; aleuroglyphus ovatus; lemongrass; ovatus ... See more keywords
Is there still a place for fast-acting neuromuscular blockade agents: fast onset or safe and prompt reversal?
Sign Up to like & getrecommendations! Published in 2025 at "Current opinion in anaesthesiology"
DOI: 10.1097/aco.0000000000001497
Abstract: PURPOSE OF REVIEW This review is timely as it addresses the ongoing challenge of developing an ideal short-acting, nondepolarizing muscle relaxant. It emphasizes the need for agents that combine a rapid onset, brief duration of… read more here.
Keywords: fast acting; reversal; neuromuscular blockade; blockade ... See more keywords
A novel class of fast‐acting antimalarial agents: Substituted 15‐membered azalides
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15292
Abstract: Efficacy of current antimalarial treatments is declining as a result of increasing antimalarial drug resistance, so new and potent antimalarial drugs are urgently needed. Azithromycin, an azalide antibiotic, was found useful in malaria therapy, but… read more here.
Keywords: antimalarial agents; acting antimalarial; class fast; fast acting ... See more keywords
Mealtime fast‐acting insulin aspart versus insulin aspart for controlling postprandial hyperglycaemia in people with insulin‐resistant Type 2 diabetes
Sign Up to like & getrecommendations! Published in 2019 at "Diabetic Medicine"
DOI: 10.1111/dme.13866
Abstract: This post hoc analysis explored whether mealtime fast‐acting insulin aspart treatment provided an advantage in postprandial plasma glucose (PPG) control vs. insulin aspart in people with Type 2 diabetes receiving high doses of bolus insulin. read more here.
Keywords: aspart; mealtime fast; insulin aspart; type diabetes ... See more keywords
Efgartigimod as a Fast‐Acting Add‐On Therapy in Antibody–Mediated Autoimmune Encephalitis
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Neurology"
DOI: 10.1111/ene.70280
Abstract: Autoimmune encephalitis (AE) is a severe neurological disorder that requires effective and safe treatment options. This study aimed to compare the efficacy and safety of intravenous methylprednisolone (IVMP) plus efgartigimod (IPE) versus IVMP alone or… read more here.
Keywords: autoimmune encephalitis; efgartigimod fast; antibody mediated; fast acting ... See more keywords
Light-activated molecular machines are fast-acting broad-spectrum antibacterials that target the membrane
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abm2055
Abstract: The increasing occurrence of antibiotic-resistant bacteria and the dwindling antibiotic research and development pipeline have created a pressing global health crisis. Here, we report the discovery of a distinctive antibacterial therapy that uses visible (405… read more here.
Keywords: machines fast; activated molecular; mms; molecular machines ... See more keywords
Appraisal of the validity of preclinical investigations to predict the efficacy of psychedelic drugs as fast-acting antidepressants.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of psychopharmacology"
DOI: 10.1177/02698811251360754
Abstract: Each incident of failure of a novel drug to translate from preclinical experiments into the clinic increases the pressure to justify the use of animals in these experiments and for the interpretation of findings to… read more here.
Keywords: fast acting; acting antidepressants; appraisal validity; preclinical investigations ... See more keywords