Fast Construction of 1,3-Benzothiazepines by Direct Intramolecular Dehydrogenative C-S Bond Formation of Thioamides under Metal-Free Conditions.
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DOI: 10.1021/acs.orglett.8b02697
Abstract: The first general protocol for the synthesis of 1,3-benzothiazepine derivatives was established. With the aid of bench-stable hypervalent iodine promoter fluoro-HTIB, these seven-membered heterocycles can be rapidly synthesized from readily available thioamides under air atmosphere… read more here.
Keywords: free conditions; benzothiazepines direct; construction benzothiazepines; fast construction ... See more keywords