Role for Fast Inactivation in Domain I of Voltage Gated Sodium Channels
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DOI: 10.1016/j.bpj.2016.11.589
Abstract: In sodium channels, the voltage sensing S4 segments move outward in response to membrane depolarization to promote activation and fast inactivation of the channel. Domain-specific roles for S4 segments include activation and fast inactivation. In… read more here.
Keywords: state fast; sodium; inactivation; fast inactivation ... See more keywords
Molecular basis of sodium channel inactivation
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DOI: 10.1038/s41467-025-65587-1
Abstract: Voltage-gated sodium channels initiate action potentials and control electrical signaling throughout the animal kingdom. Fast inactivation is an essential auto-inhibitory mechanism and requisite component of sodium channel physiology. Recent structural and electrophysiological results are inconsistent… read more here.
Keywords: sodium channel; voltage; inactivation; fast inactivation ... See more keywords
Nav1.2 channel mutations preventing fast inactivation lead to SCN2A encephalopathy
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DOI: 10.1093/brain/awae213
Abstract: Abstract SCN2A gene-related early-infantile developmental and epileptic encephalopathy (EI-DEE) is a rare and severe disorder that manifests in early infancy. SCN2A mutations affecting the fast inactivation gating mechanism can result in altered voltage dependence and… read more here.
Keywords: fast inactivation; nav1 channel; scn2a; inactivation ... See more keywords
How activation leads to gating
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DOI: 10.1126/science.363.6433.1296-k
Abstract: Ion Channels Voltage-gated sodium (Nav) channels are key players in electrical signaling. Central to their function is fast inactivation, and mutants that impede this cause conditions such as epilepsy and pain syndromes. The channels have… read more here.
Keywords: activation; science; leads gating; fast inactivation ... See more keywords
Structural basis of α-scorpion toxin action on Nav channels
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DOI: 10.1126/science.aav8573
Abstract: How activation leads to gating Voltage-gated sodium (Nav) channels are key players in electrical signaling. Central to their function is fast inactivation, and mutants that impede this cause conditions such as epilepsy and pain syndromes.… read more here.
Keywords: nav channels; scorpion; vsd4; inactivation ... See more keywords
Depolarization of the conductance-voltage relationship in the NaV1.5 mutant, E1784K, is due to altered fast inactivation
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DOI: 10.1371/journal.pone.0184605
Abstract: E1784K is the most common mixed long QT syndrome/Brugada syndrome mutant in the cardiac voltage-gated sodium channel NaV1.5. E1784K shifts the midpoint of the channel conductance-voltage relationship to more depolarized membrane potentials and accelerates the… read more here.
Keywords: voltage; conductance voltage; fast inactivation; e1784k ... See more keywords
A Novel Spider Toxin Inhibits Fast Inactivation of the Nav1.9 Channel by Binding to Domain III and Domain IV Voltage Sensors
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DOI: 10.3389/fphar.2021.778534
Abstract: Venomous animals have evolved to produce peptide toxins that modulate the activity of voltage-gated sodium (Nav) channels. These specific modulators are powerful probes for investigating the structural and functional features of Nav channels. Here, we… read more here.
Keywords: inactivation; toxin; domain; voltage ... See more keywords